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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine exposure during adolescence enhances behavioral sensitivity to nicotine during adulthood in Wistar rats.
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Nicotine exposure during adolescence enhances behavioral sensitivity to nicotine during adulthood in Wistar rats.

机译：青春期暴露于尼古丁可增强Wistar大鼠成年后对尼古丁的行为敏感性。

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RATIONALE: Drug use during adolescence is associated with an increased propensity for drug dependency during adulthood. Therefore, the effects of adolescent exposure to nicotine on adult behavioral responsiveness to nicotine are of particular importance. OBJECTIVES: The objective of the current study was to determine if adolescent nicotine exposure would enhance behavioral sensitivity and development of sensitization to nicotine during adulthood. MATERIALS AND METHODS: Male Wistar rats were assigned to one of three groups that received subcutaneous (s.c.) injections of nicotine (0, 0.25, or 0.5mg/kg) in the home cage for 12 consecutive days during adolescence, PD 31-42. Starting on PD 80, distance traveled, rearing, and stereotypy were recorded in locomotor activity chambers each day for 10 days, following s.c. injections of 0, 0.25, or 0.5mg/kg nicotine. One week later, a final challenge session took place during which rats were injected with 0.5mg/kg nicotine. RESULTS: Rats exposed to nicotine during adolescence displayed a greater locomotor response to a novel environment than saline-treated rats. Adolescent nicotine treatment also resulted in context-independent sensitization to the acute locomotor activating properties of nicotine, including distance traveled and stereotypy, as measured on the first day of adulthood nicotine exposure. Adolescent nicotine-treated rats displayed increased sensitivity to repeated nicotine exposures during adulthood, compared to adolescent saline-treated rats, as measured by distance traveled, rearing, and stereotypic behaviors. Finally, rats treated with nicotine only during adolescence were more sensitive to a final nicotine challenge during adulthood than rats treated with nicotine only previously during adulthood. CONCLUSIONS: Overall, the results suggest that adolescent nicotine treatment predisposes adult rats to develop increased behavioral sensitivity to chronic nicotine treatment and to be more sensitive to the initial effects of nicotine.
机译：理由：青春期吸毒与成年期对药物依赖的倾向增加有关。因此，青少年暴露于尼古丁对成年人对尼古丁的行为反应的影响尤为重要。目的：本研究的目的是确定青少年时期的尼古丁暴露量是否能提高成年期的行为敏感性和对尼古丁的敏感性。材料和方法：雄性Wistar大鼠被分为三组之一，在青春期PD 12-42连续12天在家里的笼子中皮下（s.c.）注射尼古丁（0、0.25或0.5mg / kg）。从PD 80开始，在s.c.之后，每天在运动活动室记录10天的行驶距离，饲养和刻板印象。注射0、0.25或0.5mg / kg尼古丁。一周后，进行了最后一次攻击，在此期间向大鼠注射了0.5mg / kg尼古丁。结果：青春期暴露于尼古丁的大鼠对新环境的运动反应比生理盐水处理的大鼠更大。青春期尼古丁治疗还导致对尼古丁的急性运动活化特性（包括行进距离和刻板印象）的上下文无关的致敏作用，这是在成年尼古丁暴露的第一天测得的。与青春期生理盐水治疗的大鼠相比，青春期尼古丁治疗的大鼠对成年后反复暴露于尼古丁的敏感性更高，这是通过行进距离，饲养和定型行为来衡量的。最后，仅在青春期接受尼古丁治疗的大鼠比成年之前仅接受尼古丁治疗的大鼠对最终的尼古丁攻击更为敏感。结论：总的来说，结果表明青春期尼古丁治疗使成年大鼠对慢性尼古丁治疗的行为敏感性增强，并且对尼古丁的初始作用更敏感。

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