• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta-lactam antibiotic, ceftriaxone, in mice.
【24h】

Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the beta-lactam antibiotic, ceftriaxone, in mice.

机译：GLT-1转运蛋白活化在预防β-内酰胺类抗生素头孢曲松钠对小鼠的大麻素耐受中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recently, it has been indicated that beta lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Furthermore, these antibiotics have been shown to prevent the development of tolerance and dependence to opioids. Since cannabinoid tolerance is known to be similar to opioids, our purpose was to examine the effect of ceftriaxone on the development of tolerance to WIN 55,212-2, a cannabinoid agonist. The tail flick test, a rectal thermometer, and the ring test were used for evaluating the degree of tolerance to the analgesic, hypothermic, and cataleptic effects of WIN 55,212-2, respectively. Within one week, animals became completely tolerant to analgesic, hypothermic and cataleptic effects of WIN 55,212-2 (6mg/kg). Ceftriaxone, with its higher doses (100-200mg/kg), attenuated the development of tolerance to the analgesic and hypothermic effects of WIN 55,212-2, but had no effect on its cataleptic action. Dihydrokainic acid (10mg/kg), a GLT-1 transporter inhibitor, prevented this effect of ceftriaxone. Our results suggest that repeated treatment with ceftriaxone prevents the development of tolerance to the analgesic and hypothermic effects of cannabinoids, and GLT-1 activation appears to play a key role in this preventive effect of beta-lactam antibiotics.
机译：最近，已经表明β内酰胺抗生素通过增加谷氨酸转运蛋白的表达来提供神经保护作用。此外，已显示这些抗生素可防止对阿片类药物产生耐受性和依赖性。由于已知大麻素的耐受性与阿片类药物相似，因此我们的目的是研究头孢曲松对大麻素激动剂WIN 55,212-2的耐受性发展的影响。甩尾试验，直肠温度计和环试验分别用于评估对WIN 55,212-2的镇痛，低温和致敏作用的耐受程度。一周之内，动物就完全耐受WIN 55,212-2（6mg / kg）的止痛，低温和致敏作用。头孢曲松钠的剂量较高（100-200mg / kg），可减轻对WIN 55,212-2的镇痛和低温作用的耐受性，但对其镇痛作用没有影响。 GLT-1转运抑制剂二氢海藻酸（10mg / kg）阻止了头孢曲松的这种作用。我们的结果表明，用头孢曲松反复治疗可预防对大麻素的镇痛和低温作用的耐受性，而GLT-1的活化似乎在β-内酰胺类抗生素的这种预防作用中起关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号