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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Spatial learning/memory and social and nonsocial behaviors in the spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rat strains.
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Spatial learning/memory and social and nonsocial behaviors in the spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rat strains.

机译：自发性高血压，Wistar-Kyoto和Sprague-Dawley大鼠品系中的空间学习/记忆以及社会和非社会行为。

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摘要

The Spontaneously Hypertensive rat (SHR) is often described as less behaviorally reactive than its normotensive strain, the Wistar-Kyoto (WKY), although results are somewhat inconsistent across studies. In part, this may be due to the lack of a definitive characterization of reactivity. WKY across studies are sometimes conflicting. Further, few comparisons with other rodent strains are available and these might provide guidance in outlining the meaning of reactivity. Here, social and nonsocial behaviors and spatial learning and memory were measured in male and female SHR, WKY, and Sprague-Dawley (SD) rats. Systolic blood pressure measurements at adulthood confirmed hypertension in the SHR. Juvenile play behavior indicated that SHRs were more sensitive to the strain of their play partner than were the WKY or SD, playing less with different strain partners than with same strain partners. However, adult dominance behavior (restricted access in a water competition test) indicated no strain differences. TheSHR appeared to exhibit attenuated acoustic startle relative to the WKY and SD and their prepulse inhibition was substantially less at higher prepulse decibel intensities; however, this decreased prepulse inhibition was not the result of decreased startle during the test. Anxiety-related behavior in the elevated plus maze was most prominent in the SD strain, possibly as a result of poorer motor coordination as measured by rotarod performance. Elevated plus maze behavior as well as motor coordination did not differ between the SHR and WKY strains. Performance in the NCTR complex maze and the Morris water maze was significantly better in the SHR. These results do not support hypotheses of decreased behavioral reactivity in the SHR strain. Rather, they suggest complex interactions between social and nonsocial environments and the behavioral capabilities and requirements of the rat strain.
机译：自发性高血压大鼠（SHR）的行为反应性通常低于其正常血压菌株Wistar-Kyoto（WKY），尽管研究结果有些不一致。部分原因可能是由于缺乏对反应性的明确表征。跨研究的WKY有时会发生冲突。此外，很少有与其他啮齿动物菌株的比较，这可能为概述反应性的含义提供指导。在这里，在雄性和雌性SHR，WKY和Sprague-Dawley（SD）大鼠中测量了社交和非社交行为以及空间学习和记忆。成年期的收缩压测量结果证实了SHR中的高血压。幼年的游戏行为表明，SHR比WKY或SD对他们的游戏伙伴的应变更为敏感，与相同的应变伙伴相比，与不同的应变伙伴相比，SHR的游戏较少。但是，成年人的主导行为（在水上竞赛测试中受限进入）表明没有应变差异。相对于WKY和SD，SHR表现出减弱的声音惊吓，并且在较高的前脉冲分贝强度下，它们的前脉冲抑制作用明显较小。但是，这种减少的前脉冲抑制力并不是测试过程中惊吓减少的结果。在高架迷宫中，与焦虑相关的行为在SD品系中最为突出，可能是由于用旋转脚踏机器人的表现来衡量的运动协调性较差。 SHR和WKY菌株之间的高迷迷宫行为以及运动协调性没有差异。 SHR在NCTR复合迷宫和Morris水迷宫中的性能明显更好。这些结果不支持SHR菌株中行为反应性降低的假设。相反，他们暗示了社会和非社会环境与大鼠品系的行为能力和要求之间的复杂相互作用。

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