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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Increasing the selectivity of the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol: complete substitution with methanandamide.
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Increasing the selectivity of the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol: complete substitution with methanandamide.

机译：增加Delta（9）-四氢大麻酚的歧视性刺激效果的选择性：用甲酰胺取代完全。

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摘要

In an attempt to increase the selectivity of the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol (THC), rats were trained to discriminate 3.2 mg/kg of this compound from a group of "other" drugs consisting of morphine (3.2 mg/kg), PCP (2.5 mg/kg), and vehicle. Acquisition of the Delta(9)-THC-other discrimination was rapid (38 days) and did not differ significantly from that of a group of "control" animals trained to discriminate Delta(9)-THC (3.2 mg/kg) from its vehicle (33 days). In substitution (generalization) tests, a high dose of anandamide, which also severely decreased response rate, substituted partially in both the control and the Delta(9)-THC-other group; (R)-methanandamide, an analog of anandamide which is metabolized more slowly, substituted completely for Delta(9)-THC in the control, and partially in the Delta(9)-THC-other group; neither pentobarbital nor diazepam substituted completely for Delta(9)-THC under any experimental condition. Regardless of the level of Delta(9)-THC lever responding, all drugs except diazepam substituted less in the Delta(9)-THC-other than in the control group. For this reason, the Delta(9)-THC-other training procedure might be described as being more selective than the commonly used drug-no drug procedure.
机译：为了增加对Delta（9）-四氢大麻酚（THC）的歧视性刺激作用的选择性，对大鼠进行了训练，使其从一组由吗啡组成的“其他”药物中区分出3.2 mg / kg的该化合物（3.2 mg / kg公斤），五氯苯酚（2.5毫克/公斤）和媒介物。获得Delta（9）-THC-其他辨别力很快（38天），与经过训练可将Delta（9）-THC（3.2 mg / kg）与其区别开来的一组“对照”动物相差无几。车辆（33天）。在替代（一般化）试验中，高剂量的anandamide（也严重降低了应答率）在对照组和Delta（9）-THC-其他组中均被部分替代; （R）-甲烷酰胺，它是代谢较慢的甲酰胺的类似物，在对照组中完全取代了Delta（9）-THC，部分取代了Delta（9）-THC-其他基团;在任何实验条件下，戊巴比妥和地西epa均不能完全取代Delta（9）-THC。不论Delta（9）-THC杠杆反应的水平如何，除地西epa外，所有药物在Delta（9）-THC-中的取代率均低于对照组。因此，可以将Delta（9）-THC-其他训练程序描述为比常用的无毒品程序更具选择性。

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