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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task.
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Estrogen has mnemonic-enhancing effects in the inhibitory avoidance task.

机译：雌激素在抑制性避免任务中具有助记忆作用。

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Gonadal hormones, such as estrogen, can alter cognitive performance. The present studies investigated the relationship between performance on the inhibitory avoidance task and endogenous fluctuations in ovarian hormones and estrogen replacement. In Experiment 1, proestrous or diestrous I female, or male, rats were trained in the inhibitory avoidance task. Following a 24-h intertrial delay, when female rats were tested in metestrus or diestrus II, no differences in crossover latencies were observed among groups. In Experiment 2, female rats in proestrus or diestrus I, and male rats, were trained in the inhibitory avoidance task and were tested following a 4-h intertrial delay (so that training and testing were accomplished in the same phase of the cycle). In this paradigm, proestrous rats had significantly longer crossover latencies than did either diestrous I or male rats. Posttraining administration of estrogen, but not progesterone, to ovariectomized rats increased crossover latencies compared to vehicle with a 4-h (Experiment 3) or 24-h (Experiment 4) intertrial delay. In Experiment 5, estrogen administration to ovariectomized rats immediately, but not 1, 2, or 3 h posttraining, increased crossover latencies compared to vehicle. Together, these data suggest that estrogen can have positive mnemonic effects in the inhibitory avoidance task.
机译：性激素，例如雌激素，可以改变认知能力。本研究调查了抑制回避任务的表现与卵巢激素和雌激素替代的内源性波动之间的关系。在实验1中，对雌性或雌性雌性或雌性雌性或雌性大鼠进行了抑制回避任务的训练。间隔24小时后，当雌性大鼠在肠test或二头肌II中进行测试时，各组之间的交叉潜伏期没有差异。在实验2中，对处于发情期或二头肌I的雌性大鼠和雄性大鼠进行了抑制回避任务的训练，并在4 h的试验间隔延迟后进行了测试（以便在周期的同一阶段完成训练和测试）。在这种范例中，与雌性或雄性大鼠相比，发情期大鼠的交叉潜伏期明显更长。与具有4小时（实验3）或24小时（实验4）的试验间隔延迟的媒介物相比，对切除卵巢的大鼠进行雌激素而不是孕酮的训练后给药，其交叉潜伏期增加。在实验5中，与赋形剂相比，立即向卵巢切除的大鼠施用雌激素，而不是在训练后1、2或3 h给予雌激素，增加了交叉潜伏期。总之，这些数据表明雌激素在抑制性避免任务中具有积极的记忆作用。

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