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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Oxazepam does not modulate the behavioral effects of d-amphetamine in humans.
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Oxazepam does not modulate the behavioral effects of d-amphetamine in humans.

机译：奥沙西m不调节d-苯异丙胺对人类的行为影响。

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摘要

Benzodiazepines, which are gamma-aminobutyric acid-A (GABA(A)) receptor positive modulators, can block the behavioral effects of psychomotor stimulants. In the present study, the ability of oxazepam, which may have less abuse potential compared to some other benzodiazepines, to attenuate the discriminative-stimulus, subject-rated and psychomotor performance effects of d-amphetamine in humans was determined. Six healthy participants (2 female, 4 male) learned to discriminate 15 mg oral d-amphetamine. After acquiring the discrimination (i.e., > or = 80% correct responding on 4 consecutive days), the effects of d-amphetamine (0, 2.5, 5, 10 and 15 mg), alone and in combination with acutely administered oxazepam (0 and 20 mg) were assessed. d-Amphetamine alone functioned as a discriminative stimulus, produced stimulant-like subject-rated effects (e.g., increased ratings of Stimulated on a Drug-Effect Questionnaire) and enhanced psychomotor performance. Oxazepam alone increased subject ratings of sedation (e.g., increased ratings of Sluggish, Fatigued and Lazy on a Drug-Effect Questionnaire) and impaired psychomotor performance. Oxazepam alone did not occasion d-amphetamine-like discriminative-stimulus effects, and had no effect on the discriminative-stimulus or subject-rated effects of d-amphetamine when given in combination. The results of this experiment are discordant with previous research and suggest that benzodiazepines differ in their ability to modulate the behavioral effects of d-amphetamine.
机译：苯二氮卓类是γ-氨基丁酸-A（GABA（A））受体阳性调节剂，可以阻断精神运动兴奋剂的行为影响。在本研究中，确定了奥沙西m与其他苯并二氮杂compared相比可能具有较小的滥用潜力，能够减弱人体内d-苯丙胺的歧视性刺激，受试者评定的和精神运动性能的作用。六名健康参与者（2名女性，4名男性）学会了区分15毫克口服d-苯异丙胺。获得辨别力（即连续4天≥80％正确应答）后，单独使用d-苯异丙胺（0、2.5、5、10和15 mg），并与急性给药的奥沙西m（0和评估20毫克）。单独的d-苯丙胺起到区分性刺激的作用，产生类似刺激物的受试者评级效应（例如，通过药物作用问卷对刺激等级进行提高）并增强精神运动能力。单独使用奥沙西m会增加受试者对镇静的评分（例如，对药物作用问卷的反应迟钝，疲劳和懒惰的评分会增加），并且会降低心理运动能力。单独使用奥沙西m不会产生d-苯丙胺类的歧视性刺激作用，并且与d-苯丙胺组合使用时，对d-苯丙胺的鉴别性刺激或受试者评价的作用均无影响。该实验的结果与先前的研究不一致，表明苯二氮卓类在调节d-苯异丙胺的行为效应上的能力不同。

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