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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral sensitization and voluntary ethanol drinking in alcohol-preferring AA rats exposed to different regimens of morphine treatment.
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Behavioral sensitization and voluntary ethanol drinking in alcohol-preferring AA rats exposed to different regimens of morphine treatment.

机译：在接受不同吗啡治疗方案的偏爱酒精的AA大鼠中的行为敏化和自愿饮酒。

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The purpose of the study was to investigate the effects of three different regimens of morphine treatment on subsequent voluntary ethanol drinking in alcohol-preferring AA (Alko Alcohol) rats. The rats were given morphine subcutaneously either intermittently on alternating days (15 x 10 mg/kg or 5 x 5-20 mg/kg in escalating doses) or subchronically on four consecutive days (3-20 mg/kg/d). Horizontal locomotor activity was monitored after challenges with additional morphine injections (3 mg/kg) ten days and six weeks after termination of the pretreatment to test if behavioral sensitization was induced by repeated morphine administration. Both intermittent pretreatments induced sensitized locomotor response after the first challenge, whereas subchronic injections did not. After the challenge the rats were given a free choice between tap water and 10% (v/v) ethanol solution for four weeks. The rats pretreated and challenged with morphine did not differ significantly in the acquisition of ethanol drinking from the saline-treated controls. In contrast, ethanol drinking was impaired during the first week of ethanol access in the saline-treated rats given a single morphine injection. The second morphine challenge given after the ethanol-drinking phase did not reveal sensitization in any of the groups. The results suggest that pattern of morphine administration rather than the dose or number of exposures to the drug is the most important factor in induction of behavioral sensitization, and that exposure to ethanol may interfere with this process. They also support earlier findings showing that acute morphine may suppress voluntary ethanol drinking, but failed to provide clear evidence for behavioral sensitization to morphine contributing to predilection towards ethanol in AA rats.
机译：这项研究的目的是研究三种不同的吗啡治疗方案对随后在偏好酒精的AA（Alko Alcohol）大鼠中自愿饮酒的影响。在交替的几天（以递增剂量的15 x 10 mg / kg或5 x 5-20 mg / kg的剂量）间断地皮下给予吗啡，或在连续四天（3-20 mg / kg / d）的皮下给予大鼠吗啡。在终止预处理后第10天和第6周用额外的吗啡注射液（3 mg / kg）刺激后，监测水平运动能力，以测试是否通过重复服用吗啡引起行为敏化。第一次挑战后，两种间歇性预处理均引起敏锐的运动反应，而亚慢性注射则没有。攻击后，让大鼠自由选择自来水和10％（v / v）乙醇溶液，持续4周。用吗啡预处理和攻击的大鼠从经盐水处理的对照组获取的乙醇摄入量方面无显着差异。相反，在接受单次吗啡注射的盐水处理大鼠中，在乙醇接触的第一周期间，乙醇的饮用受到了损害。饮酒阶段后进行的第二次吗啡刺激在所有组中均未显示致敏性。结果表明，吗啡的给药方式而不是药物暴露的剂量或次数是诱导行为敏化的最重要因素，并且暴露于乙醇可能会干扰这一过程。他们还支持较早的发现，这些发现表明急性吗啡可以抑制自愿饮酒，但是未能提供对吗啡的行为敏化作用的明确证据，从而导致AA大鼠偏向乙醇。

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