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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neurotensin levels and receptors in HAS and LAS rat brains: effects of ethanol.
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Neurotensin levels and receptors in HAS and LAS rat brains: effects of ethanol.

机译：HAS和LAS大鼠大脑中神经降压素水平和受体：乙醇的影响。

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Previous studies of neurotensin (NT) levels and NT receptor densities in specific brain regions of mice selectively bred for differences in sensitivity to ethanol have shown that NTergic processes may mediate some actions of ethanol. In the present study, we have determined the levels of NT and NT receptor densities in specific brain regions of HAS and LAS rats that have been selectively bred for differences in sensitivity to ethanol-induced loss of righting response. Regional differences in NT levels were observed in brains from both HAS and LAS rats and values in hypothalamus, ventral midbrain, and nucleus accumbens from female rats were 25 to 75% higher than levels in corresponding regions from male rats. However, there were no significant line differences in NT-ir levels in corresponding regions from HAS and LAS animals. High-affinity binding (NTH Bmax values), measured by Scatchard analyses, were higher in ventral midbrain from HAS males than from LAS males. NTH receptor densities were higher in HAS males than in HAS females; sex differences were not observed in the LAS line. There were no significant line or sex differences between HAS and LAS in low-affinity (NTL) Bmax values in any brain region. In HAS females, subhypnotic doses of ethanol produced a decrease in NT levels in nucleus accumbens, whereas, hypnotic doses caused an increase in NT levels. Likewise, hypnotic doses elicited increases in NT levels in hypothalamus of female HAS and LAS, but not in ventral midbrain or caudate putamen. These results are consistent with low dose activation of mesolimbic and nigrostriatal dopaminergic neurons in which NT is colocalized with dopamine and with high dose inhibition of these pathways.
机译：先前对小鼠特定脑区中神经降压素（NT）水平和NT受体密度进行选择性培养以研究其对乙醇敏感性的差异的先前研究表明，NT能过程可能介导乙醇的某些作用。在本研究中，我们已经确定了HAS和LAS大鼠特定脑区域中NT和NT受体密度的水平，这些水平区域已选择性繁殖，以适应乙醇诱导的扶正反应丧失的敏感性。在HAS和LAS大鼠的大脑中均观察到NT水平的区域差异，雌性大鼠的下丘脑，腹中脑和伏隔核的值比雄性大鼠相应区域的水平高25％至75％。然而，在来自HAS和LAS动物的相应区域中，NT-ir水平没有显着的差异。通过Scatchard分析测量，高亲和力结合（NTH Bmax值）在HAS男性的腹中脑中比LAS男性更高。男性HAS中的NTH受体密度高于女性。在LAS系中未观察到性别差异。在任何大脑区域中，低亲和力（NTL）Bmax值在HAS和LAS之间没有明显的性别差异或性别差异。在HAS女性中，亚催眠剂量的乙醇使伏伏核的NT水平降低，而催眠剂量导致NT的水平升高。同样，催眠剂量引起女性HAS和LAS下丘脑NT水平升高，但腹中脑或尾状壳核细胞则不升高。这些结果与中脑边缘和黑质纹状体多巴胺能神经元的低剂量活化一致，其中NT与多巴胺共定位并且对这些途径具有高剂量抑制作用。

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