• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Methadone produces conditioned place preference in the rat.
【24h】

Methadone produces conditioned place preference in the rat.

机译：美沙酮在大鼠中产生条件性位置偏爱。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The appetitive properties of methadone were investigated using the conditioned place preference paradigm. Male Sprague-Dawley rats received conditioned place preference training for a 6-day period. The apparatus consisted of two chambers with distinctive visual and tactile cues, separated by removable doors. Rats received intraperitoneal (IP) injections of methadone (1.0, 2.0, 4.0, 6.0, 8.0, and 10.0 mg/kg methadone HCl) paired with one chamber and saline paired with the other chamber on alternating days. On the seventh day, rats were allowed free run of the entire apparatus and time spent in either chamber was computer recorded. Methadone produced a place preference for the side previously paired with drug in a dose-dependent manner. Place preference for methadone peaked at 4.0 mg/kg and aversion was produced at 10.0 mg/kg. These results indicate that at intermediate doses, methadone does have appetitive properties and is capable of producing a conditioned place preference.
机译：使用条件性位置偏爱范式研究了美沙酮的食欲特性。雄性Sprague-Dawley大鼠接受了为期6天的条件化位置偏好训练。该设备由两个腔室组成，两个腔室具有独特的视觉和触觉提示，由可移动的门隔开。大鼠接受腹膜内（IP）注射美沙酮（1.0、2.0、4.0、6.0、8.0和10.0 mg / kg盐酸美沙酮），每隔一天配对一次，盐水与另一隔室配对。在第七天，允许大鼠自由运行整个装置，并且计算机记录在任一腔室中花费的时间。美沙酮对先前以剂量依赖性方式与药物配对的一侧产生了位置偏爱。对美沙酮的位置偏爱达到4.0 mg / kg的峰值，并产生10.0 mg / kg的反感。这些结果表明，在中等剂量下，美沙酮确实具有食欲性，并且能够产生条件性位置偏爱。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号