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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Ethanol anapyrexia in rats.
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Ethanol anapyrexia in rats.

机译：大鼠乙醇厌氧症。

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摘要

In the present series of experiments we tested whether ethanol decreases body temperature by impairing thermal regulation (poikilothermia) or by shifting the set point downwards. The central temperature of rats kept in a thermocline and the selected ambient temperature were recorded by telemetry. After an IP injection of 2 g/kg of ethanol the rats selected an ambient temperature 7 degrees C lower than the one they selected before the ethanol injection and 8 degrees C lower than the one selected by the same rats after saline injection. At the same time the central temperature decreased by 2.5 degrees C. After about 40 min the rats preferred warmer ambient temperatures and 10 min later the central temperature began to rise. When, after ethanol, the rats were kept at 30 degrees C the central temperature remained at the normal level. At 35-36 degrees C the central temperature of normal rats without ethanol rose, in 1 h, from 37 degrees C to 39.75 degrees C. The results suggest that ethanol hypothermia is due to a downward shift of the set point and, in fact, is an anapyrexia, a condition inverse to fever.
机译：在本系列实验中，我们测试了乙醇是否会通过破坏热调节（体温过低）或将设定点向下移动来降低体温。通过遥测记录保持在温床中的大鼠的中心温度和选择的环境温度。腹腔注射2 g / kg乙醇后，大鼠选择的环境温度比注射乙醇前选择的环境温度低7摄氏度，比相同大鼠注射盐水后选择的环境温度低8摄氏度。同时，中心温度降低了2.5摄氏度。大约40分钟后，老鼠偏爱较热的环境温度，而10分钟后，中心温度开始升高。在乙醇后，将大鼠保持在30摄氏度时，中心温度保持在正常水平。在35-36摄氏度下，没有乙醇的正常大鼠的中心温度在1小时内从37摄氏度上升到39.75摄氏度。结果表明，乙醇体温过低是由于设定点的向下移动，实际上，是一种厌食症，是发烧的逆境。

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