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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats.
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5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats.

机译：5-HT3受体拮抗剂不会改变可卡因位置调节或大鼠伏隔核中细胞外多巴胺的升高。

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摘要

Three 5-HT3 receptor antagonists, MDL 72222, tropisetron, and ondansetron were studied for their ability to modify the conditioned place preference (CPP) induced by 10 mg/kg IP cocaine in rats. MDL 72222 (0.03-3 mg/kg SC) and tropisetron (0.01-0.1 mg/kg SC) administered, respectively, 30 min and 1 h before each conditioning session, did not affect the acquisition of cocaine CPP. Ondansetron (0.01-0.1 mg/kg SC) administered 30 min before each conditioning session or just before testing likewise had no effect. At 0.1 mg/kg SC ondansetron did not modify the increase of extracellular dopamine caused by 10 mg/kg cocaine in the nucleus accumbens. The results suggest that 5-HT3 receptor antagonists have no effect on the rewarding properties of cocaine or on the behaviour elicited by the stimuli previously associated with the drug's action.
机译：研究了三种5-HT3受体拮抗剂MDL 72222，托吡司琼和恩丹西酮在大鼠中修饰10 mg / kg IP可卡因诱导的条件性位置偏爱（CPP）的能力。每次调理前30分钟和1小时分别服用MDL 72222（0.03-3 mg / kg SC）和tropisetron（0.01-0.1 mg / kg SC）不会影响可卡因CPP的获得。在每次调理前30分钟或在测试前30分钟服用恩丹西酮（0.01-0.1 mg / kg SC）同样无效。在0.1 mg / kg SC下，恩丹西酮不能改变伏隔核中10 mg / kg可卡因引起的细胞外多巴胺的增加。结果表明5-HT3受体拮抗剂对可卡因的奖励特性或先前与该药物作用有关的刺激引起的行为没有影响。

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