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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Influence of fluoxetine and paroxetine in behavioral sensitization induced by ethanol in mice.
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Influence of fluoxetine and paroxetine in behavioral sensitization induced by ethanol in mice.

机译：氟西汀和帕罗西汀对乙醇诱导的小鼠行为致敏的影响。

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The serotonergic system is involved in depression, anxiety and alcoholism. The rewarding properties of ethanol, mainly its anxiolytic and stimulant effects, as well as the development of dependence on ethanol have been related to the serotonergic system. Consequently, the use of selective serotonergic reuptake inhibitors (SSRI) has been proposed in the treatment of alcoholism. In this study we investigated whether acute administration of the SSRIs fluoxetine or paroxetine is able to (i) reverse the behavioral effects induced by chronic ethanol consumption, and conversely, (ii) to determine whether acute ethanol is able to substitute for the chronically induced behavioral effects of fluoxetine or paroxetine. Four groups of male Swiss mice (n=60/group) received daily i.p. saline, ethanol (2 g/kg), fluoxetine (10 mg/kg) or paroxetine (5 mg/kg) for 27 days. On the 28th day, each group was challenged with saline, ethanol, fluoxetine or paroxetine. The 14 groups (SS, SE, SP, SF, EE, ES, EP, EF, PP, PE, PS, FF, FE, and FS) were then tested in open field, activity cage and plus-maze. EP and EF groups were able to reverse the behavioral sensitization to the psychomotor stimulant effects of chronic ethanol administration. In contrast, a sensitized stimulatory effect was observed in chronically fluoxetine- or paroxetine treated mice challenged with ethanol (PE and FE). An anxiolytic effect was observed whether ethanol was substituted for SSRI or, conversely, SSRI was substituted for ethanol. SSRIs facilitated ethanol-induced locomotor sensitization, although SSRIs by themselves are unable to produce the locomotor stimulation similar to that induced by ethanol. Finally, SSRIs are unable to interfere in the ethanol anxiolytic effect.
机译：血清素能系统涉及抑郁症，焦虑症和酒精中毒。乙醇的有益特性，主要是其抗焦虑和刺激作用，以及对乙醇依赖性的发展与血清素能系统有关。因此，已经提出在治疗酒精中毒中使用选择性5-羟色胺再摄取抑制剂（SSRI）。在这项研究中，我们调查了SSRIs氟西汀或帕罗西汀的急性给药是否能够（i）逆转由长期饮酒引起的行为影响，反之，（ii）确定急性乙醇是否能够代替慢性诱发的行为氟西汀或帕罗西汀的影响。每天接受四组雄性瑞士小鼠（n = 60 /组）。盐水，乙醇（2 g / kg），氟西汀（10 mg / kg）或帕罗西汀（5 mg / kg）处理27天。在第28天，每组接受盐水，乙醇，氟西汀或帕罗西汀的攻击。然后在开阔地，活动笼和迷宫中测试了这14组（SS，SE，SP，SF，EE，ES，EP，EF，PP，PE，PS，FF，FE和FS）。 EP和EF组能够逆转长期服用乙醇对精神运动刺激作用的行为敏感性。相反，在用乙醇（PE和FE）攻击的经氟西汀或帕罗西汀治疗的慢性小鼠中观察到敏化的刺激作用。无论是用乙醇代替SSRI还是相反，用SSRI代替乙醇，都可以观察到抗焦虑作用。尽管SSRI本身无法产生类似于乙醇诱导的运动刺激，但SSRI促进了乙醇诱导的运动致敏。最后，SSRIs不能干扰乙醇的抗焦虑作用。

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