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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Impact of water temperature and stressor controllability on swim stress-induced changes in body temperature, serum corticosterone, and immobility in rats.
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Impact of water temperature and stressor controllability on swim stress-induced changes in body temperature, serum corticosterone, and immobility in rats.

机译：水温和应激源可控性对游泳应激诱导的大鼠体温，血清皮质酮和固定性变化的影响。

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摘要

The present study compared the effects of three different water temperatures (20, 25, and 30 degrees C) and stressor controllability on several physiological and behavioral endpoints in an intermittent swim stress paradigm. The escape latency of rats in the 20 and 25 degrees C water was less than that observed for the 30 degrees C group. Both escape and yoked groups at 20 and 25 degrees C exhibited moderate to severe hypothermia following the swim stress session that returned to prestress levels 30-40 min post-stress. At 30 degrees C core body temperature (Tb) only decreased by 1 degree C for either swim group. Following swim, serum corticosterone (CORT) levels were significantly elevated in both escape and yoked groups in comparison to confined and home cage controls. The confined control group showed a significant elevation that was approximately halfway between the home cage control and the swim stress groups. At 30 degrees C, there was still a significant elevation of serum CORT in both swim groupsin comparison to confined and home cage controls. Therefore, 30 degrees C appears to be the optimal water temperature to evaluate stress controllability effects in the current paradigm. In a final experiment, swim stressor controllability effects were examined in a 5 min forced swim test (FST) 24 h following the initial stress exposure. Rats exposed to yoked-inescapable swim stress at 30 degrees C exhibited more immobility than their escapable swim stress and confined counterparts, while the escape and confined controls did not differ. These results demonstrate that the behavioral deficits observed in the FST are attributable to the stress of inescapable swim and not swim stress per se.
机译：本研究比较了三种不同水温（20、25和30摄氏度）和应激源可控性对间歇游泳应激范式中几个生理和行为终点的影响。大鼠在20和25摄氏度水中的逃避潜伏期比30摄氏度组的逃避潜伏期短。游泳应激后，在20和25摄氏度下逃脱组和带轭组都表现出中等至严重的体温过低，在应激后30-40分钟恢复到应激前水平。在任一游泳组中，核心温度（Tb）在30摄氏度时仅降低了1摄氏度。游泳后，与密闭和笼养对照组相比，逃跑组和轭铁组的血清皮质酮（CORT）水平均显着升高。受限的对照组显示出明显的升高，大约在家庭笼对照组和游泳压力组之间。在30摄氏度时，与密闭和笼养对照组相比，两个游泳组的血清CORT仍显着升高。因此，在当前范式中，30摄氏度似乎是评估应力可控性效果的最佳水温。在最终实验中，在初始压力​​暴露后24小时的5分钟强迫游泳测试（FST）中检查了游泳应激源的可控性效果。与可逃避的游泳压力和密闭的同伴相比，暴露于30摄氏度的无轭铁游泳压力的大鼠表现出更多的固定性，而逃跑和密闭的对照没有差异。这些结果表明，在FST中观察到的行为缺陷可归因于不可避免的游泳压力，而不是游泳压力本身。

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