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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Fenfluramine treatment in female rats accelerates the weight loss associated with activity-based anorexia.
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Fenfluramine treatment in female rats accelerates the weight loss associated with activity-based anorexia.

机译：在雌性大鼠中使用芬氟拉明治疗可加速与基于活动的厌食症相关的体重减轻。

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摘要

Serotonin plays an important role in controlling food intake and regulating body weight. Thus, altered serotonergic function may be involved in the etiology of anorexia nervosa. To investigate this hypothesis, we examined whether activation of the serotonin system increases the severity of activity-based anorexia, an animal model of anorexia nervosa in which food-restricted rats are housed with access to running wheels. This paradigm promotes symptoms of anorexia nervosa, including hypophagia, hyperactivity, and weight loss. Food-restricted rats received injections of a serotonin agonist, fenfluramine, or saline 1.5 h prior to their daily 2-h period of food access. A third saline-injected group was pair-fed to the fenfluramine group. Drug treatment and food restriction were terminated following a 25% weight loss. During food restriction, each group developed symptoms of activity-based anorexia. Although similar reductions in food intake were observed in fenfluramine-treated and pair-fed rats, only fenfluramine-treated rats displayed an accelerated rate of weight loss, relative to saline-treated rats. Thus, some other nonanorexic aspect of fenfluramine, perhaps its influence on metabolism, must underlie the accelerated rate of weight loss in this group. Our results suggest that increased activation of the serotonin system exacerbates the weight loss associated with activity-based anorexia.
机译：5-羟色胺在控制食物摄入和调节体重方面起着重要作用。因此，改变的血清素能功能可能与神经性厌食症的病因有关。为了研究这个假设，我们检查了5-羟色胺系统的激活是否增加了基于活动的厌食症的严重程度，这种厌食症是一种神经性厌食症的动物模型，在该模型中，食物受限的大鼠可以通过跑轮进食。这种范例促进了神经性厌食症的症状，包括吞咽不足，活动过度和体重减轻。限制食物的大鼠在每天2小时的食物获取前1.5小时接受5-羟色胺激动剂，芬氟拉明或盐水的注射。第三个注射盐水的组与芬氟拉明组配对喂养。减肥25％后终止药物治疗和食物限制。在食物限制期间，每个小组都会出现活动性厌食症状。尽管在芬氟拉明治疗和成对喂养的大鼠中观察到相似的食物摄入减少，但是相对于盐水治疗的大鼠，仅芬氟拉明治疗的大鼠显示出体重减轻的速率加快。因此，芬氟拉明的其他一些非厌食性方面，可能是它对代谢的影响，必须成为该组减肥速度加快的基础。我们的结果表明，血清素系统激活的增加加剧了与基于活动的厌食症相关的体重减轻。

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