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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reversal of apomorphine locomotor sensitization by a single post-conditioning trial treatment with a low autoreceptor dose of apomorphine: A memory re-consolidation approach.
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Reversal of apomorphine locomotor sensitization by a single post-conditioning trial treatment with a low autoreceptor dose of apomorphine: A memory re-consolidation approach.

机译：通过使用低自动受体剂量的阿扑吗啡的单次条件后试验治疗来逆转阿扑吗啡的运动致敏作用：一种记忆再巩固方法。

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摘要

Sensitization is a common feature of psychostimulants and sensitization effects are generally considered to be linked to the addictive properties of these drugs. We used a conventional paired/unpaired Pavlovian protocol to induce a context specific sensitization to the locomotor stimulant effect of a high dose of apomorphine (2.0mg/kg). Two days following a 5 session sensitization induction phase, a brief 5min non-drug test for conditioning was conducted. Only the paired groups exhibited locomotor stimulant conditioned response effects. Immediately following this brief test for conditioning, the paired and the unpaired groups received injections of 0.05mg/kg apomorphine, 2.0mg/kg apomorphine or vehicle designed to differentially impact memory re-consolidation of the conditioning. Two days later, all groups received a sensitization challenge test with 2.0mg/kg apomorphine. The 2.0mg/kg apomorphine post-trial treatment potentiated sensitization while the 0.05mg/kg eliminated sensitization. These effects were only observed in the paired groups. The activation of dopaminergic systems by the high dose of apomorphine strengthened the drug/environment association whereas the inhibition of dopamine activity by the low auto-receptor dose eliminated this association. The results point to the importance of conditioning to context specific sensitization and targeting memory re-consolidation of conditioning as a paradigm to modify sensitization.
机译：敏化是精神刺激药的共同特征，敏化作用通常被认为与这些药物的成瘾性有关。我们使用常规的配对/未配对的Pavlovian方案诱导对高剂量阿扑吗啡（2.0mg / kg）的运动刺激作用的情境特异性致敏。在5个阶段的致敏诱导阶段后两天，进行了简短的5分钟非药物调理试验。只有成对的组表现出运动刺激条件反应作用。在进行简短的调理测试后，配对和未配对的组立即注射了0.05mg / kg的阿扑吗啡，2.0mg / kg的阿扑吗啡或设计用于差异性影响调理记忆再巩固的媒介物。两天后，所有组均接受了2.0mg / kg阿扑吗啡的致敏性激发试验。试验后2.0mg / kg的阿扑吗啡可增强致敏性，而0.05mg / kg的阿扑吗啡可消除致敏性。这些效果仅在配对组中观察到。高剂量的阿扑吗啡对多巴胺能系统的激活增强了药物/环境的联系，而低自身受体剂量对多巴胺活性的抑制则消除了这种联系。结果表明条件对上下文特定的敏化和针对条件的记忆重新整合的条件作为修改敏化的范式的重要性。

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