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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice.
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Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice.

机译：奥氮平，塞地多尔和氯氮平对MK-801诱导的小鼠视觉记忆障碍的影响。

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We investigated the effects of the second generation antipsychotics olanzapine, sertindole and clozapine on visual recognition memory using the novel object recognition (NOR) test in naive and MK-801-treated animals. The effects of drug treatment on locomotion and anxiety were also determined using the open field test. Male Balb-c mice were treated with olanzapine (0.2, 0.4 and 0.6 mg/kg; i.p.), sertindole (0.63, 1.3 and 2.5mg/kg; s.c.) or clozapine (0.5 and 1mg/kg; i.p.), and cognitive deficits were induced by MK-801 (0.2mg/kg; i.p.) administration. Olanzapine treatment decreased the ratio index in the NOR test, whereas sertindole and clozapine had no effect in naive mice. MK-801-induced cognitive impairment was reversed by treatment with olanzapine, sertindole or clozapine. While olanzapine, sertindole and clozapine had no effect on the anxiety of naive mice as determined by the open field test, MK-801 significantly increased the total distance traveled, time spent in the center zone and the velocity of the animals. MK-801-induced effects on locomotion and anxiety in the open field test were reversed by olanzapine, sertindole or clozapine treatment. The results of the present study demonstrated that olanzapine, sertindole and clozapine improved cognition in MK-801 treated mice, and indicate that these drugs have a potential to improve cognition in schizophrenia.
机译：我们调查了天真的和MK-801治疗的动物中使用新型对象识别（NOR）测试的第二代抗精神病药物奥氮平，塞地多尔和氯氮平对视觉识别记忆的影响。药物治疗对运动和焦虑的影响也使用开场试验确定。用Olanzapine（0.2、0.4和0.6 mg / kg; ip），sertindole（0.63、1.3和2.5mg / kg; sc）或clozapine（0.5和1mg / kg; ip）治疗雄性Balb-c小鼠和认知缺陷通过MK-801（0.2mg / kg;腹膜内）给药诱导。在NOR试验中，奥氮平治疗降低了比率指数，而赛多度和氯氮平对幼稚小鼠没有影响。 MK-801诱导的认知障碍可通过奥氮平，塞多多或氯氮平治疗来逆转。通过开放野外试验确定，奥氮平，塞地多尔和氯氮平对幼稚小鼠的焦虑没有影响，但MK-801显着增加了总的行进距离，在中心区域所花费的时间以及动物的速度。奥氮平，塞地多尔或氯氮平治疗可逆转MK-801对运动和焦虑的影响，在野外试验中则相反。本研究的结果表明，奥氮平，塞地多尔和氯氮平可改善MK-801治疗小鼠的认知，并表明这些药物具有改善精神分裂症认知的潜力。

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