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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Adriamycin-related anxiety-like behavior, brain oxidative stress and myelotoxicity in male Wistar rats.
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Adriamycin-related anxiety-like behavior, brain oxidative stress and myelotoxicity in male Wistar rats.

机译：在雄性Wistar大鼠中，阿霉素相关的焦虑样行为，脑部氧化应激和骨髓毒性。

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摘要

Chemotherapeutic regimens have been indicated to negatively impact the quality of life for patients. Adriamycin (ADR) is an effective chemotherapeutic agent widely employed for the treatment of human's malignancies; however, it may cause serious side effects. The present study was aimed at investigating the effects of acute administration of ADR on cognitive alterations, brain oxidative status and immune dysregulation in male Wistar rats. Treated animals received a single intraperitoneal injection of ADR (7 mg/kg). Control ones received physiological saline only. Behavioral effects were tested in the elevated plus-maze and the open field which showed that drug-treated rats displayed anxious behavior and deteriorations in the locomotive and exploratory activities over the 72 h following ADR injection as compared to controls. Assessment of brain antioxidant capacity in ADR-injected animals revealed an increase in glutathione-S-transferase activities and malondialdehyde levels while a decrease in glutathione concentrations when compared with the vehicle-treated group. Our results indicated that ADR administration decreased total leukocyte, lymphocyte and granulocyte counts, while enhanced monocyte levels. Moreover, white blood cells (WBC) relative counts in ADR-treated rats showed a significant increase in monocytes and granulocytes and a decrease in lymphocytes as compared to controls. This study suggests that ADR-related cognitive impairments are associated with brain oxidative stress and myelosuppression.
机译：已经表明化学疗法对患者的生活质量有负面影响。阿霉素（ADR）是一种有效的化学治疗剂，广泛用于治疗人类恶性肿瘤;但是，这可能会导致严重的副作用。本研究旨在调查急性ADR对雄性Wistar大鼠认知改变，脑氧化状态和免疫失调的影响。经治疗的动物接受腹膜内注射ADR（7 mg / kg）。对照组仅接受生理盐水。在升高的迷宫和开阔的视野中测试了行为效果，结果表明，与对照组相比，药物治疗的大鼠在注射ADR后72小时内表现出焦虑行为，并且机车和探索性活动恶化。与溶媒治疗组相比，对注射ADR的动物进行脑抗氧化能力的评估显示，谷胱甘肽S转移酶活性和丙二醛水平增加，而谷胱甘肽浓度下降。我们的结果表明，ADR给药可减少总白细胞，淋巴细胞和粒细胞计数，同时增加单核细胞水平。此外，与对照组相比，ADR治疗大鼠的白细胞（WBC）相对计数显示单核细胞和粒细胞显着增加，而淋巴细胞则减少。这项研究表明，与ADR相关的认知障碍与脑部氧化应激和骨髓抑制有关。

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