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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >GABAergic drugs inhibit amphetamine-induced distractibility in the rat.
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GABAergic drugs inhibit amphetamine-induced distractibility in the rat.

机译：GABA药物抑制大鼠中苯丙胺引起的注意力分散。

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摘要

Drugs facilitating GABAergic neurotransmission have been reported to block some behavioral actions of dopaminergic stimulation but not others. The present experiments were performed with the purpose to extend the range of behaviors in which the interaction between GABA and dopamine have been studied. The ability of the GABAB agonist baclofen and the GABA transaminase inhibitor sodium valproate to block the enhanced distractibility produced by amphetamine was evaluated in a procedure especially designed for analyzing drugs' effects on distractibility. Briefly, rats were trained to traverse a straight runway with a sucrose solution as reinforcement. Once the response had been acquired, an additional runway ending in an empty box was connected. The time spent investigating this additional runway is the measure of distractibility. Male rats treated with amphetamine, 1 mg/kg, displayed an increase of the time spent in the additional runway. Baclofen, 2.5 and 5 mg/kg, and sodium valproate, 100 and 200 mg/kg,had no effect on distraction behavior when administered alone. However, when these drugs were administered together with amphetamine, 1 mg/kg, they completely inhibited the effects of the stimulant on distractibility. These data show that distractibility is similar to discrimination learning with regard to the capacity of GABAergic drugs to block the effects of dopaminergic stimulation. It is different from locomotor activity, however, where GABAergic drugs are ineffective in this respect.
机译：据报道，促进GABA能神经传递的药物可以阻止多巴胺能刺激的某些行为，但不能阻止其他行为。进行本实验的目的是扩大研究GABA与多巴胺之间相互作用的行为范围。 GABAB激动剂巴氯芬和GABA转氨酶抑制剂丙戊酸钠阻断苯丙胺产生的增强分散性的能力已通过专门设计用于分析药物对分散性影响的程序进行了评估。简而言之，训练大鼠以蔗糖溶液作为补强剂穿过直线跑道。获取响应后，将连接以空框结尾的附加跑道。研究这条额外跑道所花费的时间是分散注意力的量度。用1 mg / kg苯丙胺治疗的雄性大鼠在其他跑道上的停留时间增加。单独给药时，巴氯芬2.5和5 mg / kg，丙戊酸钠100和200 mg / kg，对分心行为没有影响。然而，当这些药物与苯丙胺1 mg / kg一起给药时，它们完全抑制了兴奋剂对分散性的影响。这些数据表明，就GABA药物阻止多巴胺能刺激的作用而言，分散性类似于歧视学习。然而，它与运动活动不同，在这种情况下，GABA能药物无效。

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