• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nitric oxide synthase inhibition impairs delayed recall in mature monkeys.
【24h】

Nitric oxide synthase inhibition impairs delayed recall in mature monkeys.

机译：一氧化氮合酶抑制作用削弱了成年猴子的延迟回忆。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The gaseous neuromodulator nitric oxide (NO) is formed in brain regions known to mediate learning and memory processes. In rodent models, pharmacologic inhibition of NO synthesis impairs such processes. In the present study, N omega-nitro-L-arginine methyl ester (L-Name), an inhibitor of the constitutive form of the NO synthetic enzyme, was administered to seven non-aged, mature monkeys (Macaca Fascicularis, Macaca Mulatta, and Macaca Nemestrima) trained to perform a delayed matching-to-sample task (DMTS). L-Name (1.5, 25, and 50 mg/kg) produced marked decrements in task performance, as well as a reduction in the number of trials completed at the highest dose. This impairment of DMTS accuracy by the 50 mg/kg doses of L-Name appears to be associated with an aversive state marked by gastrointestinal disturbance and lethargy. The detrimental effects of the 25 mg/kg dose of L-Name on DMTS accuracy were completely blocked by concurrent administration of a mole-equivalent dose of the NO amino acid precursor L-arginine. As a whole, these data suggest that L-Name impairs processes involved in delayed recall in monkeys and that this impairment is associated with attenuated synthesis of NO. However, at higher doses (> or = 25 mg/kg) this impairment is associated with aversive effects of L-Name, possibly at both central and peripheral sites.
机译：气态神经调节剂一氧化氮（NO）在已知介导学习和记忆过程的大脑区域中形成。在啮齿动物模型中，NO合成的药理抑制作用会削弱此类过程。在本研究中，将NO合成酶组成型抑制剂Nω-硝基-L-精氨酸甲酯（L-Name）施用给了7只未成年的成熟猴子（猕猴，猕猴，和Macaca Nemestrima）受过训练，可以执行延迟的采样匹配（DMTS）任务。 L-Name（1.5、25和50 mg / kg）导致任务表现显着下降，并且最高剂量下完成的试验次数减少。 50 mg / kg剂量的L-Name对DMTS准确性的损害似乎与胃肠道紊乱和嗜睡引起的厌恶状态有关。通过同时施用摩尔当量的NO氨基酸前体L-精氨酸，可以完全阻止25 mg / kg剂量的L-Name对DMTS准确性的有害影响。总体而言，这些数据表明L-Name损害了猴子延迟召回的过程，并且这种损害与NO的合成减弱有关。但是，在较高剂量（>或= 25 mg / kg）下，这种损害可能与L-Name的厌恶作用有关，可能在中枢和外周部位都有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号