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Bromocriptine enhances feeding behavior without changing dopamine metabolism.

机译:溴隐亭在不改变多巴胺代谢的情况下增强了喂养行为。

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Bromocriptine is an ergot derivative and has been thought to act as a selective D2 receptor agonist, but its effects on dopamine release in vivo have not been confirmed. We administered bromocriptine into the striatum of rats and studied the effects on feeding behavior and dopamine release. Bromocriptine was perfused via a microdialysis probe into the ventrolateral striatum of rats fasted for 22 h, and the rats were then allowed to feed freely for 6 h. Bromocriptine perfusion increased food intake in a dose-dependent manner, whereas the extracellular concentrations of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) did not change. Perfusion of (-) sulpiride, a selective D2 receptor antagonist, decreased food intake, but increased dopamine release and the levels of DOPAC and HVA. Pretreatment with (-)sulpiride perfusion for 1 h prior to bromocriptine perfusion inhibited the increase of food intake induced by bromocriptine, and it increased dopamine release and the levels ofDOPAC and HVA. These findings suggest that bromocriptine directly perfused into the ventrolateral striatum acts selectively on postsynaptic D2 receptors and enhances feeding behavior.
机译:溴隐亭是麦角衍生物,被认为是选择性的D2受体激动剂,但尚未证实其对体内多巴胺释放的作用。我们向大鼠纹状体中施用了溴隐亭,并研究了其对喂养行为和多巴胺释放的影响。通过微透析探针将溴隐亭注入禁食22 h的大鼠腹侧纹状体中,然后让大鼠自由进食6 h。溴隐亭灌注以剂量依赖的方式增加食物摄入量,而细胞外多巴胺,3,4-二羟基苯基乙酸(DOPAC)和高香草酸(HVA)的浓度没有变化。选择性的D2受体拮抗剂(-)舒必利的灌注减少了食物摄入,但增加了多巴胺的释放以及DOPAC和HVA的水平。溴隐亭灌注前用(-)舒必利灌流预处理1 h可抑制溴隐亭诱导的食物摄入增加,并增加多巴胺释放以及DOPAC和HVA的水平。这些发现表明直接注入腹侧纹状体的溴隐亭选择性作用于突触后D2受体并增强了进食行为。

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