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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of L-NOARG on plus-maze performance in rats.
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Effects of L-NOARG on plus-maze performance in rats.

机译：L-NOARG对大鼠迷宫性能的影响。

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摘要

Nitric oxide (NO) synthase, the enzyme responsible for NO formation, is located in brain regions such as amygdala and dorsolateral central grey, regions which are known to be involved in anxiety. To investigate the possible role of NO in anxiety, rats received acute i.p. injections of NG-nitro-l-arginine (L-NOARG, 7.5-120 mg kg-1), an inhibitor of NO synthase, and were tested in the elevated plus maze, an animal model of anxiety. The drug, at doses of 30-120 mg kg-1, decreased the percentage of entries and time spent on the open arms of the maze, but these doses, with exception of 30 mg, also decreased the number of entries into enclosed arms. These effects disappeared when the animals were tested after chronic L-NOARG treatment (3.75 to 60 mg kg-1 i.p., twice a day for four days). The effects of acute i.p. injection of 30 mg kg-1 of L-NOARG were blocked by i.c.v. pretreatment with 1000 nmol of l-arginine (but not 500 nmol). Thus, inhibition of NO formation in the central nervous system seems to decrease exploration of the elevated plus maze, an effect that disappears after four days of chronic (twice a day) L-NOARG administration.
机译：一氧化氮（NO）合酶是负责NO形成的酶，位于大脑区域，如杏仁核和背外侧中央灰色，这些区域已知与焦虑有关。为了研究NO在焦虑症中的可能作用，大鼠接受了急性腹膜内注射。注射一氧化氮合酶抑制剂NG-硝基-1-精氨酸（L-NOARG，7.5-120 mg kg-1），并在高架迷宫（一种焦虑动物模型）中进行了测试。该药物的剂量为30-120 mg kg-1，减少了进入迷宫开放臂的进入百分比和时间，但是这些剂量（30 mg例外）也减少了进入封闭臂的进入数量。在对动物进行慢性L-NOARG治疗后（3.75至60 mg kg-1 i.p.，每天两次，共四天）进行测试时，这些作用消失了。急性腹膜炎的影响i.c.v阻断了30 mg kg-1的L-NOARG注射。用1000 nmol的L-精氨酸（但不是500 nmol）进行预处理。因此，抑制中枢神经系统中NO的形成似乎会减少对高架迷宫的探索，这种效果在连续四天（每天两次）给予L-NOARG后消失。

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