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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Chronic intermittent heroin produces locomotor sensitization and long-lasting enhancement of conditioned reinforcement.
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Chronic intermittent heroin produces locomotor sensitization and long-lasting enhancement of conditioned reinforcement.

机译：慢性间歇性海洛因可产生运动性敏化作用，并能长期增强条件增强作用。

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In a previous study we showed that chronic intermittent heroin in rats enhanced responding with conditioned reinforcement and reversal learning of a conditioned magazine approach task when tested three days after the heroin treatment. Whether or not this enhanced appetitive learning persists after a protracted withdrawal period remains unknown and constitutes the aim of the present study. Forty-eight male Long Evans rats were each exposed to positive pairings of a light stimulus and food for 4 consecutive daily sessions. Then, two groups of rats received saline and two groups received heroin (2 mg/kg) injections before placement in activity monitors for 9 consecutive daily sessions. This was followed by testing in operant conditioning chambers where one lever produced the light stimulus previously paired with food and another no stimulus. For one saline and one heroin group this testing occurred after 2 days of withdrawal while for the other saline and heroin groups it occurred after 30 days of withdrawal. The results indicate that animals treated with heroin displayed progressively and significantly greater locomotor activity across sessions while animals treated with saline displayed locomotor activity that remained low and stable across sessions. In addition, the heroin groups in each withdrawal condition displayed significantly enhanced responding with conditioned reinforcement compared to their respective saline control groups. These results demonstrate that chronic intermittent heroin enhances appetitive learning for natural reinforcers and motivational processes and that this effect persists even after 30-days of withdrawal.
机译：在先前的研究中，我们显示，在海洛因治疗三天后进行测试时，大鼠中的慢性间歇性海洛因通过条件强化和条件杂志方法的逆向学习增强了反应。在延长的戒断期后是否继续增强食欲学习仍然未知，这构成了本研究的目的。将48只雄性Long Evans雄性大鼠每天连续4次暴露于光刺激和食物的正配对。然后，两组大鼠接受生理盐水注射，两组接受海洛因（2 mg / kg）注射，然后放置在连续9天每天的活动监测器中。随后在操作性调节室内进行测试，其中一个杠杆产生的光刺激先前与食物配对，而另一个则没有刺激。对于一个盐水和一个海洛因组，该试验在停药后2天进行，而对于其他盐水和海洛因组，该试验在停药30天后进行。结果表明，用海洛因治疗的动物在整个疗程中表现出逐渐增强的运动能力，而用生理盐水治疗的动物在整个疗程中表现出低而稳定的运动能力。此外，与各自的生理盐水对照组相比，在每种戒断条件下的海洛因组显示出条件增强后的反应显着增强。这些结果表明，慢性间歇性海洛因可增强自然补强剂和动机过程的食欲学习，并且即使停药30天后这种效果仍会持续。

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