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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The anxiolytic effect of testosterone in the rat is mediated via the androgen receptor
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The anxiolytic effect of testosterone in the rat is mediated via the androgen receptor

机译：睾丸激素对大鼠的抗焦虑作用是通过雄激素受体介导的

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Endogenous and exogenous testosterone affects several behavioural traits as shown in human and animal studies. The effects of testosterone can be mediated via androgen or oestrogen receptors, but also via rapid non-genomic effects. The aim of this study was to evaluate whether a single testosterone injection has effects, mediated via the androgen receptor, on anxiety in intact male rats. We hypothesised that administration of testosterone will have an anxiolytic effect, mediated by the androgen receptor. Intact adult male Wistar rats were divided into groups: control, flutamide, testosterone and testosterone with flutamide. Testosterone and flutamide (as an androgen receptor blocker) were applied once, intramuscularly, at a dose of 5 mg/kg. Twenty four hours later, rats underwent the following behavioural tests to analyse anxiety: open field test, elevated plus maze and light-dark box. Testosterone was measured in plasma to confirm elevated levels in groups that received testosterone. The levels of testosterone were 2.5-3 fold higher amongst rats administered with testosterone compared to controls. Flutamide did not affect plasma testosterone concentrations. Testosterone administration had no effect on anxiety in the open field and elevated plus maze. In the light-dark transition task, testosterone increased the time spent in the light part of the maze by 80%, an effect which was blocked by flutamide, and which was in support of our hypothesis. Flutamide-treated rats spent more time in the central square of the open field. Using the light-dark box we have shown that a single injection of testosterone decreases anxiety in adult male rats. This effect of increased testosterone was mediated via the androgen receptor as flutamide blocked the anxiolytic effect of exogenous testosterone. Treatment with flutamide blocked the effects of endogenous testosterone and had anxiolytic effects in the open field, suggesting a non-linear relationship between genomic effects of T and anxiety.
机译：内源性和外源性睾丸激素会影响人类和动物研究中显示的几种行为特征。睾丸激素的作用可以通过雄激素或雌激素受体介导，也可以通过快速的非基因组作用介导。这项研究的目的是评估单次睾丸激素注射是否通过雄激素受体介导对完整雄性大鼠的焦虑产生影响。我们假设睾丸激素的给药将具有雄激素受体介导的抗焦虑作用。将完整的成年雄性Wistar大鼠分为两组：对照组，氟他胺，睾丸激素和含氟他胺的睾丸激素。肌内注射一次睾丸激素和氟他酰胺（作为雄激素受体阻滞剂），剂量为5 mg / kg。二十四小时后，大鼠接受以下行为测试以分析焦虑：露天测试，高架迷宫和明暗盒子。测量血浆中的睾丸激素水平，以确认接受睾丸激素治疗的组水平升高。与对照组相比，在服用睾丸激素的大鼠中，睾丸激素的水平高2.5-3倍。氟他胺不影响血浆睾丸激素浓度。睾丸激素的施用对旷野和高架迷宫中的焦虑没有影响。在明暗过渡任务中，睾丸激素使迷宫中浅色部分所花费的时间增加了80％，这种效果被氟他胺所阻止，这支持了我们的假设。用氟他胺治疗的大鼠在开阔地带的中央广场上花费了更多的时间。使用明暗框显示，单次注射睾丸激素可减少成年雄性大鼠的焦虑。睾丸激素升高的这种作用是通过雄激素受体介导的，因为氟他米特阻断了外源性睾丸激素的抗焦虑作用。氟他胺治疗可阻断内源性睾丸激素的作用，并在开放领域具有抗焦虑作用，这表明T基因组效应与焦虑之间存在非线性关系。

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