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MK-801 induces a low intensity conditioned taste aversion

机译：MK-801引起低强度的条件性厌味

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摘要

N-methyl-d-aspartate (NMDA) receptor antagonists are often used to assess the role of NMDA receptors in learning and memory processes. However, few studies have explored the possibility that the antagonists may induce a conditioned aversion when administered following flavor consumption. We report five experiments with rats intended to evaluate the MK-801 capacity to induce conditioned taste aversion. Our findings suggest that: i) MK-801 produces a low-intensity aversion following repeated pairings with saccharin (Experiments 1 and 2); ii) such aversion was not the result of a non-associative process (Experiment 3); and iii) pre-exposure to MK-801 does not interact with conditioned taste aversion induced by lithium chloride (Experiments 4 and 5). These findings suggest that MK-801 induces a low-intensity aversion, although the underlying mechanisms of this aversion may differ from those of a conditioned aversion produced by lithium chloride.
机译：N-甲基-d-天冬氨酸（NMDA）受体拮抗剂通常用于评估NMDA受体在学习和记忆过程中的作用。但是，很少有研究探索在食用风味剂后服用拮抗剂可能引起条件性厌恶的可能性。我们报告了五个旨在评估MK-801诱导条件性味觉厌恶能力的大鼠实验。我们的发现表明：i）MK-801与糖精反复配对后产生低强度厌恶（实验1和2）; ii）这种厌恶不是非联系过程的结果（实验3）; iii）预先暴露于MK-801与氯化锂诱导的条件性厌恶感不发生相互作用（实验4和5）。这些发现表明，MK-801诱导了低强度厌恶，尽管这种厌恶的潜在机制可能与氯化锂产生的条件性厌恶的机制不同。

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