• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine
【24h】

Morris water maze performance deficit produced by intermittent swim stress is partially mediated by norepinephrine

机译：间歇性游泳压力产生的莫里斯水迷宫性能缺陷部分由去甲肾上腺素介导

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Intermittent swim stress (ISS) exposes a rat to cold water and the effects of the procedure produce detrimental results on activity measures 24 h later. The ISS model can be used with the Morris water maze (MWM) to investigate the impact of stress on a spatial learning and memory task, known to involve the hippocampus. We investigated if the ISS model produced performance deficits in the MWM (experiments 1 and 2). We also investigated the role of norepinephrine by using an alpha-2 adrenergic agonist (i.e., clonidine) to exacerbate ISS-induced deficits (experiment 3), and using antidepressants (i.e., desipramine and reboxetine) that enhance the synaptic availability of norepinephrine to reduce ISS-induced deficits (experiments 4 and 5). Results indicated a main effect for stress in all experiments, with the exception of experiment 2, as ISS did induce performance deficits in the MWM. Clonidine enhanced ISS-induced deficits only in the learning trials, while desipramine and reboxetine reduced ISS-induced deficits in the learning trials. Additionally, only reboxetine reduced memory deficits in the MWM. These findings provide evidence that norepinephrine may act as a partial mediator of ISS-induced deficits in MWM performance.
机译：间歇性游泳压力（ISS）使大鼠暴露于冷水中，并且该程序的效果在24小时后对活动度产生不利影响。 ISS模型可与莫里斯水迷宫（MWM）一起使用，以研究压力对空间学习和记忆任务（已知涉及海马体）的影响。我们调查了ISS模型是否在MWM中产生了性能缺陷（实验1和2）。我们还研究了去甲肾上腺素的作用，方法是使用α-2肾上腺素能激动剂（例如可乐定）来加剧ISS引起的缺陷（实验3），并使用抗抑郁药（即去昔拉明和瑞波西汀）增强去甲肾上腺素的突触可用性以减少ISS引起的缺陷（实验4和5）。结果表明，除实验2外，所有实验均对压力产生主要影响，因为ISS确实会导致MWM的性能下降。可乐定仅在学习试验中增加了ISS引起的缺陷，而地昔帕明和瑞波西汀在学习试验中减少了ISS引起的缺陷。另外，仅瑞波西汀减少了MWM中的记忆缺陷。这些发现提供了证据证明去甲肾上腺素可能是ISS引起的MWM功能缺陷的部分介体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号