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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >GABA A and dopamine receptors in the nucleus accumbens shell differentially influence performance of a water-reinforced progressive ratio task
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GABA A and dopamine receptors in the nucleus accumbens shell differentially influence performance of a water-reinforced progressive ratio task

机译：伏隔核壳中的GABA A和多巴胺受体差异地影响水增强的递进比例任务的性能

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Several authors have shown that injections of the GABA A agonist muscimol into the medial shell region of the nucleus accumbens (AcbSh) result in large increases in food, but not water, intake. In previous studies we demonstrated that intra-AcbSh injections of either muscimol or of the indirect dopamine agonist amphetamine increase response output on a food-reinforced progressive ratio schedule. In the current experiment we extended these observations by examining the effects of muscimol and amphetamine injections on the performance of a water-reinforced progressive ratio task in mildly deprived animals. We found that muscimol did not affect the number of responses made in the water-reinforced task, even though a marked increase in responding was observed after amphetamine. Muscimol did, however, significantly increase food intake in the same animals. The results suggest that the enhancing effects of intra-AcbSh muscimol differ from those of amphetamine in that they are selective for food-reinforced behaviors.
机译：几位作者表明，向伏伏核（AcbSh）的内侧壳区域注射GABA A激动剂麝香酚会导致食物摄入量的大量增加，而不会增加水的摄入量。在以前的研究中，我们证明了在麝香酚或间接多巴胺激动剂苯丙胺内注射AcbSh可以增加食物强化的渐进比例表的反应输出。在目前的实验中，我们通过检查麝香酚和苯丙胺注射液对轻度剥夺动物的水强化递进比例任务的作用的影响，扩展了这些观察结果。我们发现，即使在安非他明后观察到了明显的应答增加，麝香酚也不会影响在水强化任务中做出的应答数量。但是，Muscimol确实显着增加了相同动物的食物摄入量。结果表明，AcbSh内麝香酚的增强作用与苯丙胺不同，因为它们对食物强化行为具有选择性。

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