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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters
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A role for 5-HT1A receptors in the basolateral amygdala in the development of conditioned defeat in Syrian hamsters

机译：5-HT1A受体在基底外侧杏仁核在叙利亚仓鼠条件性失败发展中的作用

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The basolateral nucleus of the amygdala (BLA) is a key brain region regulating behavioral changes following stressful events, including social defeat. Previous research has shown that activation of serotonin (5-HT) 1A receptors in the BLA reduces conditioned fear and anxiety-like behavior. The objective of this study was to test whether 5-HT1A receptors in the BLA contribute to conditioned defeat in male Syrian hamsters (Mesocricetus auratus). We tested whether injection of the selective 5-HT1A receptor agonist flesinoxan (400 ng, 800 ng, or 1200 ng in 200 nl saline) into the BLA prior to social defeat would reduce the acquisition of conditioned defeat, and whether a similar injection prior to testing would reduce the expression of conditioned defeat. We also tested whether injection of the selective 5-HT1A receptor antagonist WAY-100635 (400 ng or 1600 ng in 200 nl saline) into the BLA prior to social defeat would enhance the acquisition of conditioned defeat, and whether a similar injection prior to testing would enhance the expression of conditioned defeat. We found that injection of flesinoxan into the BLA decreased both the acquisition and expression of conditioned defeat. However, injection of WAY-100635 into the BLA did not alter the acquisition or expression of conditioned defeat. These data indicate that pharmacological activation of 5-HT1A receptors in the BLA is sufficient to impair the acquisition and expression of conditioned defeat. Our results suggest that pharmacological treatments that activate 5-HT1A receptors in the BLA are capable of reducing the development of stress-induced changes in behavior.
机译：杏仁核（BLA）的基底外侧核是调节压力事件（包括社交失败）后行为变化的关键大脑区域。先前的研究表明，BLA中5-羟色胺（5-HT）1A受体的激活减少了条件性恐惧和类似焦虑的行为。这项研究的目的是测试BLA中的5-HT1A受体是否有助于条件性地破坏雄性叙利亚仓鼠（Mesocricetus auratus）。我们测试了在社交失败之前向BLA注射选择性5-HT1A受体激动剂flesinoxan（400 ng，800 ng或1200 ng于200 nl盐水中）是否会减少条件性失败的获得，以及是否在类似的注射之前测试将减少条件失败的表达。我们还测试了在社交失败之前向BLA注射选择性5-HT1A受体拮抗剂WAY-100635（200毫升生理盐水中为400 ng或1600 ng）是否会增强条件性失败的获得，以及在测试之前是否进行类似注射会增强条件性失败的表达。我们发现向BLA注射flesinoxan会减少条件性失败的获得和表达。但是，将WAY-100635注入BLA并不会改变条件性失败的获得或表达。这些数据表明，BLA中5-HT1A受体的药理激活足以损害条件性失败的获得和表达。我们的结果表明，激活BLA中的5-HT1A受体的药物治疗能够减少因压力引起的行为变化。

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