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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lesion of medial prefrontal cortex reduces morphine-induced extracellular dopamine level in the ventral tegmental area: A microdialysis study in rats
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Lesion of medial prefrontal cortex reduces morphine-induced extracellular dopamine level in the ventral tegmental area: A microdialysis study in rats

机译：内侧前额叶皮层病变可降低吗啡诱导的腹侧被盖区细胞外多巴胺水平：大鼠微透析研究

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摘要

Drug addiction is a chronic disorder characterized by compulsive drug-seeking behavior despite severe negative consequences. Most abused drugs increase dopamine release in the ventral tegmental area (VTA) and in the nucleus accumbens (NA). The medial prefrontal cortex (mPFC), a part of the mesocorticolimbic dopaminergic system, receives dopaminergic projections from VTA; and in turn, sends glutamatergic projections to both VTA and NA. The present study was designed to further investigate the involvement of the mPFC in the release of dopamine in the VTA by using in vivo microdialysis and high performance liquid chromatography with electrochemical detection (HPLC-ECD). Electrical lesion of the mPFC decreased the level of dopamine in the VTA to approximately 26.8% of basal level. Acute morphine (40 mg/kg i.p.) treatment increased the level of dopamine in the VTA, while the lesion of mPFC immediately before morphine administration attenuated the effects of acute morphine on the level of dopamine. These results suggest that the mPFC modulates dopamine release into the VTA.
机译：吸毒成瘾是一种慢性疾病，尽管有严重的负面后果，但其特征是强迫性的寻求毒品行为。大多数滥用药物会增加腹侧被盖区（VTA）和伏隔核（NA）中的多巴胺释放。内侧前额叶皮层（mPFC）是中皮层边缘多巴胺能系统的一部分，从VTA接收多巴胺能投射;然后向VTA和NA发送谷氨酸能预测。本研究旨在通过体内微透析和电化学检测高效液相色谱（HPLC-ECD）进一步研究mPFC与VTA中多巴胺释放的关系。 mPFC的电损伤将VTA中的多巴胺水平降低至基础水平的约26.8％。急性吗啡（40 mg / kg i.p.）治疗可增加VTA中的多巴胺水平，而在立即服用吗啡之前的mPFC病变减轻了急性吗啡对多巴胺水平的影响。这些结果表明，mPFC调节多巴胺释放到VTA中。

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