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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The analgesic activity and possible mechanisms of deacetyl asperulosidic acid methyl ester from Ji shi teng in mice
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The analgesic activity and possible mechanisms of deacetyl asperulosidic acid methyl ester from Ji shi teng in mice

机译：吉士腾去乙酰阿魏酸甲酯的镇痛活性及可能的机制

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摘要

Deacetyl Asperulosidic Acid Methyl Ester (DAAME) from Ji shi teng was evaluated on analgesic activity in mice using chemical and thermal models of nociception. Given intraperitoneally, DAAME, at doses of 40 and 80 mg/kg, produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid, subplantar formalin/capsaicin injections and on thermal nociception in the tail-flick test and in the hot plate test. In the open-field test and the rotarod test, DAAME couldn't impair the motor performance, indicating that the observed antinociception was unlikely due to motor abnormality. In a measurement of core body temperature, DAAME (80 mg/kg) did not affect temperature within 80 min. Moreover, DAAME-induced antinociception in the capsaicin test and the hot plate test was significantly antagonized by glibenclamide. The results suggested that DAAME-produced antinociception was possibly involved in the ATP sensitive K + channels in the capsaicin test and the hot plate test, which merited exploring further.
机译：使用伤害和伤害的化学和热模型评估了吉士腾的去乙酰基阿魏酸二甲酯（DAAME）的镇痛活性。腹膜内给药，剂量为40和80 mg / kg的DAAME，对甩尾试验和热板试验中的腹膜内乙酸，formal下福尔马林/辣椒素注射液诱导的化学伤害和热伤害具有明显的抑制作用。在野外试验和旋转试验中，DAAME不会损害运动性能，表明观察到的抗伤害感受不太可能是由于运动异常引起的。在测量核心体温时，DAAME（80 mg / kg）在80分钟内不影响温度。此外，在辣椒素试验和热板试验中DAAME诱导的抗伤害感受明显被格列本脲拮抗。结果表明，在辣椒素试验和热板试验中，DAAME产生的抗伤害感受可能与ATP敏感的K +通道有关，值得进一步探讨。

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