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Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory

机译：GABA和谷氨酸门控氯通道在嗅觉记忆中的作用的证据

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摘要

In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning using a single-trial olfactory conditioning paradigm. The GABAergic antagonist picrotoxin (PTX) or the GluCl antagonist l-trans-pyrrolidine-2,4-dicarboxylic acid (l-trans-PDC) was injected alone or in combination into the α-lobes of MBs. PTX impaired early long-term olfactory memory when injected before conditioning or before testing. l-trans-PDC alone induced no significant effect on learning and memory but induced a less specific response to the conditioned odor. When injected before PTX, l-trans-PDC was able to modulate PTX effects. These results emphasize the role of MB GABA-gated chloride channels in consolidation processes and strongly support that GluCls are involved in the perception of the conditioned stimulus.
机译：在蜜蜂中，我们调查了蘑菇体（MBs）的GABA门控氯离子通道和谷氨酸门控氯离子通道（GluCls）介导的传播在使用单试验嗅觉调节范例的嗅觉学习中的作用。将GABA能拮抗剂微毒素（PTX）或GluCl拮抗剂1-反-吡咯烷-2,4-二羧酸（1-反-PDC）单独或组合注射到MBs的α瓣中。在调理之前或测试之前注射PTX会损害早期的长期嗅觉记忆。单独的l-trans-PDC对学习和记忆没有明显影响，但对条件气味的特异性反应较弱。当在PTX之前注射时，I-trans-PDC能够调节PTX效应。这些结果强调了MB GABA门控氯离子通道在固结过程中的作用，并强烈支持GluCls参与条件刺激的感知。

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