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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Decision time and perseveration of adolescent rats in the T-maze are affected differentially by buspirone and independent of 5-HT-1A expression
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Decision time and perseveration of adolescent rats in the T-maze are affected differentially by buspirone and independent of 5-HT-1A expression

机译：丁螺环酮对T迷宫中青春期大鼠的决策时间和毅力有不同的影响，并且独立于5-HT-1A表达

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摘要

Disruption of spontaneous alternation behavior (SAB) by the serotonin 1A (5-HT-1A) receptor agonist, 8-hydroxy-dipropylaminotetraline (8-OH-DPAT), results in repetitive behaviors that have been used to model the perseveration and indecisiveness of human obsessive-compulsive disorder (OCD). In the present study, we compared the effects of buspirone to those of 8-OH-DPAT in two strains of adolescent rats and analyzed repetitive choices of arms of the maze and prolonged apparent decision time due to induction of vicarious trial and error (VTE) behavior. In adolescent Sprague-Dawley (SD) rats, 8-OH-DPAT induced repetitive choices of arms of the maze (perseveration) and increased the apparent decision time. Buspirone induced VTE behavior and increased apparent decision time without perseveration. This distinct effect of buspirone was seen in SD adolescents but not in Long-Evans (LE) adolescents which appeared to be insensitive to buspirone. Lack of responsiveness to buspirone was dependent on the developmental stage because buspirone induced VTE behavior and prolonged decision time in LE adults. Western blotting of brain 5-HT-1A receptors showed expression of receptor protein in adolescent LE brain was comparable to that of adolescent SD and adult LE. The 5-HT-1A antagonist WAY 100365 blocked the effect 8-OH-DPAT on repetitive choice of arms but not the effect of buspirone on VTE behavior. We conclude that the adolescent LE rat has normal levels of 5-HT-1A receptor and that the effect of buspirone on VTE behavior is not mediated by the 5-HT-1A receptor. The LE strain may provide a useful system for further study of the adolescent brain and potential genetic differences in induction of repetitive behaviors.
机译：血清素1A（5-HT-1A）受体激动剂8-羟基-二丙基氨基四氢呋喃（8-OH-DPAT）对自发交替行为（SAB）的破坏导致重复行为已被用于建模对人的坚持和犹豫不决的行为人类强迫症（OCD）。在本研究中，我们比较了丁螺环酮和8-OH-DPAT在两种青春期大鼠中的作用，并分析了迷宫臂的重复选择，以及由于替代试验和错误（VTE）的诱导而延长了明显的决策时间。行为。在青春期的Sprague-Dawley（SD）大鼠中，8-OH-DPAT诱导了迷宫臂的重复选择（持久性）并增加了明显的决策时间。丁螺环酮可诱导VTE行为并增加明显的决策时间，而无需毅力。丁螺环酮的这种独特作用在SD青少年中可见，而在对丁螺环酮不敏感的Long-Evans（LE）青少年中则未见。对丁螺环酮缺乏反应取决于发育阶段，因为丁螺环酮会诱发LE成人的VTE行为并延长决策时间。大脑5-HT-1A受体的蛋白质印迹显示，青春期LE大脑中受体蛋白的表达与青春期SD和成人LE相当。 5-HT-1A拮抗剂WAY 100365阻止了8-OH-DPAT对重复选择臂的作用，但对丁螺环酮对VTE行为的作用没有阻止。我们得出的结论是，青春期LE大鼠具有正常水平的5-HT-1A受体，而丁螺环酮对VTE行为的影响不是由5-HT-1A受体介导的。 LE品系可能为进一步研究青春期大脑和诱导重复性行为的潜在遗传差异提供有用的系统。

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