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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Influence of nitric oxide agents in the dorsal hippocampus of mice on anxiogenic-like effect induced by histamine
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Influence of nitric oxide agents in the dorsal hippocampus of mice on anxiogenic-like effect induced by histamine

机译：一氧化氮对小鼠海马背侧神经元的影响

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Histaminergic receptors and neuronal nitric oxide synthase (nNOS) are co-expressed at high levels in the hippocampal neurons and alter anxiety-like behaviors in rodents. Since the dorsal hippocampus may be involved in modulation of anxiety-like behaviors, the aim of the present study was to assess whether the nitric oxide (NO) system in the dorsal hippocampus affects anxiety-like behaviors induced by histaminergic agents in mice. The effects of the NO precursor, L-arginine and NOS inhibitor, L-nitro-amino-methyl-ester (L-NAME) on histamine, pyrilamine and ranitidine responses in elevated plus maze (E.P.M.) in mice were investigated. Intra-CA1 microinjection of histamine (9 μg/mouse) or H1 receptor antagonist, pyrilamine (3, 6 and 9 μg/mouse), but not H2 receptor antagonist, ranitidine decreased the percentage of open arm time (%OAT) and open arm entries (%OAE), without affecting locomotor activity, suggesting an anxiogenic-like response. Both L-arginine (0.4 and 0.8 μg/mouse) and L-NAME (40 ng/mouse) when injected into the dorsal hippocampus induced anxiety-like behaviors, but the drugs reversed the anxiogenic response induced by the effective dose of histamine (9 μg/mouse) or pyrilamine (9 μg/mouse). Our results also indicated that intra-CA1 administration of L-arginine and L-NAME, in the presence or absence of ranitidine, exerted an anxiogenic effect. The results may indicate a modulatory role for NO in the dorsal hippocampus in the anxiogenic-like response induced by histamine or pyrilamine.
机译：组胺能受体和神经元一氧化氮合酶（nNOS）在海马神经元中高水平共表达，并改变啮齿动物的焦虑样行为。由于背侧海马可能参与了焦虑样行为的调节，因此本研究的目的是评估背海马中的一氧化氮（NO）系统是否会影响组胺药在小鼠中引起的焦虑样行为。研究了NO前体，L-精氨酸和NOS抑制剂，L-硝基-氨基-甲基酯（L-NAME）对小鼠高架迷宫（E.P.M.）中组胺，吡胺和雷尼替丁反应的影响。组胺（9μg/小鼠）或H1受体拮抗剂吡咯胺（3、6和9μg/小鼠）的CA1内注射，但H2受体拮抗剂，雷尼替丁未注射的情况下，雷尼替丁降低了开臂时间（％OAT）和开臂的百分比条目（％OAE），而不影响运动活性，提示类似焦虑症的反应。当将L-精氨酸（0.4和0.8μg/小鼠）和L-NAME（40 ng /小鼠）注入背侧海马时均会诱发焦虑样行为，但该药物逆转了有效剂量组胺引起的焦虑反应（9微克/小鼠）或吡拉明（9微克/小鼠）。我们的结果还表明，在存在或不存在雷尼替丁的情况下，CA-1内给予L-精氨酸和L-NAME均会产生焦虑作用。结果可能表明在海马背海马中NO的调节作用在组胺或吡胺引起的血管生成样反应中。

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