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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effect of baclofen and AP-7 on selected behavior in rats.
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The effect of baclofen and AP-7 on selected behavior in rats.

机译：巴氯芬和AP-7对大鼠选择行为的影响。

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摘要

Synaptic plasticity, cognitive performance, learning, and memory appear to be determined by the balance between GABAergic inhibitory and glutaminergic excitatory amino acids (EAA). To evaluate this role of amino acids the effects of baclofen (0.5 mg/kg IP), GABA-B receptor agonist and AP-7 (5 nmol ICV)-NMDA (N-methyl-D-aspartate) receptor antagonist on the processes of retrieval, consolidation of conditioned reflexes, object recognition, and locomotor activity were tested in rats. Neither AP-7 nor baclofen alone changed locomotor activity, but coadministration of AP-7 and baclofen significantly decreased this activity in the open-field test. Neither AP-7 nor baclofen influenced retrieval or consolidation in the passive avoidance situation when administered alone. Significantly prolonged retrieval and consolidation were observed when AP-7 and baclofen were given together. We did not find differences in effects of either AP-7 or baclofen on object recognition, regardless whether administered alone or in combination.
机译：突触可塑性，认知能力，学习和记忆似乎由GABA能抑制性和谷氨酰胺能性兴奋性氨基酸（EAA）之间的平衡决定。为了评估氨基酸的作用，巴氯芬（0.5 mg / kg IP），GABA-B受体激动剂和AP-7（5 nmol ICV）-NMDA（N-甲基-D-天冬氨酸）受体拮抗剂的作用在大鼠中测试了恢复，条件反射的巩固，物体识别和运动能力。 AP-7和baclofen都不能单独改变运动活性，但在露天试验中，AP-7和baclofen的共同给药显着降低了该活性。单独使用时，AP-7和巴氯芬对被动回避情况均不会影响恢复或巩固。当一起使用AP-7和巴氯芬时，观察到明显延长的恢复和巩固时间。无论是单独施用还是联合施用，我们都没有发现AP-7或巴氯芬对对象识别的影响存在差异。

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