首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome.
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Evaluation of risperidone in the neonatal 6-hydroxydopamine model of Lesch-Nyhan syndrome.

机译:利培酮在Lesch-Nyhan综合征的新生儿6-羟基多巴胺模型中的评估。

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摘要

Rats were treated as neonates with 6-hydroxydopamine (6-OHDA) 100 mg free base in 10 microl intracisternally. Upon maturation, animals were injected with L-dopa and placed in photocell cages for monitoring of locomotion, stereotypies, and self-mutilation. Pretreatment with either risperidone or SCH-23390 significantly reduced locomotion and stereotypies. SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject.
机译:大鼠用10毫升脑池内6-羟基多巴胺(6-OHDA)100 mg游离碱作为新生大鼠。成熟后,向动物注射左旋多巴并放置在光电池笼中,以监测运动,刻板印象和自残。利培酮或SCH-23390的预处理可显着降低运动和刻板印象。 SCH-23390消除了所有受试者中左旋多巴引起的自残,而利培酮消除了除一名受试者外所有受试者的自残。

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