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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Maturation of the biphasic behavioral and heart rate response in the formalin test.
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Maturation of the biphasic behavioral and heart rate response in the formalin test.

机译：福尔马林测试中双相行为和心率反应的成熟度。

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The biological processes that mediate and modulate the perception of pain in the infant animal are not well studied and thus nociception during early development is poorly understood. In the adult animal, injection of formalin into the hind paw produces distinct phases of behavioral and autonomic responses: an early nociceptive response followed by a period of quiescence and a later second phase that matches or exceeds the initial response. The delayed reaction of the second phase has been suggested to be a model of inflammation-induced changes in neuronal sensitivity. Studies in the infant rat have demonstrated that the first phase is present in the fetus and neonate but the onset of the second phase is later maturing. We report here that the first phase occurs in 7- to 35-day-old pups in the formalin test when measured behaviorally and in 14- to 35-day-old pups when assessed by increased heart rate. However, the behavioral response in second phase is greatly attenuated or absent in 7- or 14-day-old pups, a finding consistent with that of others, appearing first at 21 days of age. The biphasic tachycardic response was not noted until even later, at 35 days of age. These data confirm that the neural mechanisms that mediate the secondary behavioral phase in the formalin test are late maturing, that the biphasic cardiovascular response does not occur until substantially later, after weaning, and that the behavioral and cardiovascular responses are dissociated developmentally.
机译：尚未很好地研究介导和调节婴幼儿疼痛感的生物学过程，因此人们对早期发育过程中的伤害感受知之甚少。在成年动物中，将福尔马林注射到后爪中会产生行为和自主反应的不同阶段：早期的伤害性反应，然后是一段时间的静止状态，以及随后的第二阶段，其达到或超过初始反应。第二阶段的延迟反应被认为是炎症诱导神经元敏感性变化的模型。在婴儿大鼠中的研究表明，胎儿和新生儿中存在第一阶段，但第二阶段的开始较晚成熟。我们在这里报告说，第一阶段发生在福尔马林测试中的7至35天大的幼崽，从行为上进行测量，而14至35天大的幼崽在通过增加的心率评估时发生。但是，在7或14天大的幼崽中，第二阶段的行为反应大大减弱或不存在，这一发现与其他幼崽的发现一致，最早出现于21日龄。直到三十五岁时才注意到双相心动过速反应。这些数据证实，在福尔马林测试中介导次要行为阶段的神经机制已经成熟，断奶后直到实质上晚才发生双相性心血管反应，并且行为和心血管反应在发育上也分离了。

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