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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of castration and gonadal hormones on insulin-induced drinking.
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Effect of castration and gonadal hormones on insulin-induced drinking.

机译：去势和性腺激素对胰岛素诱导的饮酒的影响。

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摘要

Female Wistar rats in any of the estrual phases have been shown to drink significantly more water than males (p < 0.05), after a single I.P. insulin injection (5 U/kg b.wt.). Sexual differences in insulin-induced drinking persisted after castration when it was made in adult rats (4.6 +/- 1.2 ml/2 h, males = 8; vs. 13.0 +/- 3.1 ml/2 h, females = 8; p < 0.05). On the other hand, when animals were castrated before puberty or when newborn, sexual differences in insulin-induced drinking disappeared. Hence, insulin-induced drinking seems to be a sex-dependent phenomenon that differentiates just before or during puberty since it is abolished by castration prior to sexual maturation. Sex hormone administration in male and female rats castrated at different ages showed a variety of actions on insulin-induced drinking. A pattern emerged showing that androgenized (testosterone treated) rats drank usually less in response to insulin than estrogen-treated rats (independent of their genetic sex). According to the above results, we can conclude that insulin-induced drinking is a phenomenon sensible to gonadal hormones, both by conditioning the differentiation of some physiological structure or mechanisms that underlay drinking behavior in that paradigm and by a direct action on these or other related mechanisms.
机译：雌性Wistar大鼠在任何一次雌性阶段都显示出一次饮水后，其饮水量明显多于雄性（p <0.05）。胰岛素注射（5 U / kg体重）。成年大鼠去势后胰岛素诱导的饮酒仍然存在性别差异（4.6 +/- 1.2 ml / 2 h，雄性= 8; vs 13.0 +/- 3.1 ml / 2 h，雌性= 8; p < 0.05）。另一方面，当动物在青春期之前被cast割或新生时，胰岛素诱导的饮酒中的性别差异就消失了。因此，胰岛素诱导的饮酒似乎是一种性别依赖性现象，正好在青春期之前或之中有所区别，因为它在性成熟之前被去势所废除。在不同年龄cast割的雄性和雌性大鼠中，性激素的给药对胰岛素诱导的饮酒具有多种作用。出现了一种模式，显示雄激素化（睾丸激素治疗）的大鼠对胰岛素的反应通常比雌激素治疗的大鼠（与它们的遗传性别无关）更少。根据以上结果，我们可以得出结论，胰岛素引起的饮酒是一种对性腺激素敏感的现象，既可以通过调节某些生理结构或机制来支持饮酒的行为，又可以通过对这些或其他相关因素的直接作用来进行调节机制。

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