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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of LSD, ritanserin, 8-OH-DPAT, and lisuride on classical conditioning in the rabbit.
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Effects of LSD, ritanserin, 8-OH-DPAT, and lisuride on classical conditioning in the rabbit.

机译：LSD，ritanserin，8-OH-DPAT和lisuride对家兔经典调理的影响。

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摘要

d-Lysergic acid diethylamide (LSD), an agonist at the 5-HT(2A/2C) and 5-HT1A receptors, has previously been demonstrated to enhance associative learning as measured by accelerated acquisition of the rabbit's classically conditioned nictitating membrane (NM) response. The present study examined further the role of these receptors in the action of LSD. LSD (30 nmol/kg, I.V.) significantly enhanced conditioned response (CR) acquisition to both tone and light conditioned stimuli (CSs), while the 5-HT1A receptor agonists 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT; 50 and 200 nmol/kg) and lisuride (0.3-30 nmol/kg) had no effect. Ritanserin (6.7-6700 nmol/kg, S.C.), a selective 5-HT(2A/2C) receptor antagonist, retarded acquisition of CRs to both tone and light CSs in a dose-dependent manner. Ritanserin (6.7-670 nmol/kg, S.C.) also dose dependently antagonized the enhancement of CR conditioning produced by LSD (30 nmol/kg, I.V.) to both tone and light CSs. We conclude that the enhancement of CR acquisition by LSD was due to an action at the 5-HT(2A/2C) receptor. These results suggest that the 5-HT(2A/2C) receptor plays an important role in learning.
机译：d-麦角酰二乙酰胺（LSD）是5-HT（2A / 2C）和5-HT1A受体的激动剂，以前已被证明可以增强联想学习，这是通过加速采集兔子的经典条件化膜（NM）来衡量的响应。本研究进一步检查了这些受体在LSD作用中的作用。 LSD（30 nmol / kg，IV）显着增强了对音调和光照条件刺激（CSs）的条件响应（CR）的获取，而5-HT1A受体激动剂8-羟基-2-（二丙基氨基）四氢化萘（8-OH- DPAT; 50和200 nmol / kg）和利苏利特（0.3-30 nmol / kg）无效。 Ritanserin（6.7-6700 nmol / kg，S.C.），一种选择性的5-HT（2A / 2C）受体拮抗剂，以剂量依赖的方式将CR的捕获延迟到音调和光CS。利丹色林（6.7-670 nmol / kg，S.C.）还剂量依赖性地抑制了LSD（30 nmol / kg，I.V.）对音调和轻弹CS产生的CR调节的增强。我们得出结论，通过LSD增强CR的获得是由于对5-HT（2A / 2C）受体的作用。这些结果表明5-HT（2A / 2C）受体在学习中发挥重要作用。

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