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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of a single exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on macro- and microstructures of feeding and drinking in two differently TCDD-sensitive rat strains.
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Effects of a single exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on macro- and microstructures of feeding and drinking in two differently TCDD-sensitive rat strains.

机译：一次暴露于2,3,7,8-四氯二苯并-对-二恶英（TCDD）对两种不同TCDD敏感的大鼠品系的进食和饮水的宏观和微观结构的影响。

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In rats, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes anorexia that may lead to fatal wasting but has hitherto been poorly characterized. Therefore, we studied in-depth feeding and drinking behaviors of TCDD-sensitive L-E rats for 5 (100 mug/kg; lethal dose) or 10 (10 mug/kg; sublethal) days and of TCDD-resistant H/W rats for 14 (100 or 1000 mug/kg; both sublethal) days postexposure to TCDD. The 1000-fold higher resistance of H/W rats to acute lethality of TCDD results from a mutation in their AH receptor (AHR). We split days into four (morning, daytime, evening, and night) or two (light/dark) circadian periods and took the repeated nature of the data into account. In L-E rats at 100 mug/kg, the feed intake dropped precipitously, due to reduced meal sizes. In H/W rats, the hypophagia remained moderate and stemmed from a reduced meal frequency. While the suppression in L-E rats peaked during the morning (at 100 mug/kg), the main effects in H/W rats were seen during the constant light or dark phases. Furthermore, chronologic data analysis revealed alterations in consecutive feeding and drinking patterns. Thus, striking differences were found between these strains in the timing and structure of consummatory behaviors, suggesting involvement of the AHR in these behaviors.
机译：在大鼠中，2,3,7,8-四氯二苯并-对-二恶英（TCDD）引起厌食，可能导致致命的浪费，但迄今尚未得到很好的表征。因此，我们研究了对TCDD敏感的LE大鼠在5天（100杯/千克;致死剂量）或10天（10杯/ kg;亚致死性）下的进食和饮水行为，以及对TCDD抗性的H / W大鼠14天的进食和饮水行为暴露于TCDD后的天数（100或1000杯/千克;均处于半致死状态）。 H / W大鼠对TCDD急性致死性的抵抗力高1000倍是由其AH受体（AHR）突变引起的。我们将日期分为四个（早晨，白天，晚上和晚上）或两个（亮/暗）昼夜节律，并考虑了数据的重复性质。在L-E大鼠中，每杯100公斤/千克的饲料摄入量由于进食量的减少而急剧下降。在H / W大鼠中，吞咽不足保持中度并且是由于进餐频率降低引起的。虽然L-E大鼠的抑制作用在早晨达到峰值（100杯/千克），但在恒定的亮或暗阶段，可以看到H / W大鼠的主要作用。此外，按时间顺序的数据分析显示，连续的进食和饮水方式有所变化。因此，发现这些菌株之间在消费行为的时间和结构上存在显着差异，表明AHR参与了这些行为。

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