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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Caffeine-induced taste aversions in Lewis and Fischer rat strains: differential sensitivity to the aversive effects of drugs.
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Caffeine-induced taste aversions in Lewis and Fischer rat strains: differential sensitivity to the aversive effects of drugs.

机译：咖啡因引起的Lewis和Fischer大鼠品味厌恶感：对药物厌恶作用的敏感性不同。

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摘要

Lewis (LEW) and Fischer 344 (F344) rat strains have been reported to differ in the aversive effects induced by a number of drugs. The present studies extended this previous work and examined the ability of caffeine to induce taste aversions in the two strains. Specifically, LEW and F344 rats were given access to saccharin and injected with varying doses of caffeine (0, 0.32, 1.0 and 3.2mg/kg-Experiment 1; 0, 10, 18 and 32 mg/kg-Experiment 2). Additionally, the effects of caffeine on locomotor activity were examined in Experiment 2. At low doses (Experiment 1), caffeine failed to induce taste aversions in either strain. At higher doses (Experiment 2), aversions were induced that were strain dependent. Specifically, caffeine induced taste aversions in both strains at 32 mg/kg, while 18 mg/kg caffeine was effective in inducing aversions only in the LEW strain. Caffeine increased activity in both strains with no strain difference. This demonstration adds to the growing list of drugs on which the LEW and F344 strains differ in relation to their affective properties. Given that drug use and abuse are a function of the balance of the rewarding and aversive effects of drugs, understanding such strain differences may provide insight into the biological (and genetic) factors impacting abuse vulnerability.
机译：据报道，Lewis（LEW）和Fischer 344（F344）大鼠品系在多种药物引起的厌恶作用方面有所不同。本研究扩展了先前的工作，并研究了咖啡因在两种菌株中引起口感厌恶的能力。具体而言，使LEW和F344大鼠获得糖精，并注射不同剂量的咖啡因（0、0.32、1.0和3.2mg / kg实验1; 0、10、18和32 mg / kg实验2）。另外，在实验2中检查了咖啡因对运动能力的影响。在低剂量下（实验1），咖啡因未能在任一菌株中引起口感厌恶。在较高剂量下（实验2），诱导了与应变有关的厌恶。具体而言，咖啡因在两种菌株中均引起了32 mg / kg的口味厌恶，而18 mg / kg咖啡因仅在LEW菌株中有效诱导了厌恶。咖啡因增加了两种菌株的活性，没有菌株差异。这种证明增加了越来越多的药物，其中LEW和F344菌株在情感特性方面有所不同。鉴于毒品的使用和滥用是毒品的奖励和厌恶效果之间的平衡，因此了解这种毒株差异可以深入了解影响滥用脆弱性的生物学（和遗传）因素。

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