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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Behavioral cross-sensitization between DOCA-induced sodium appetite and cocaine-induced locomotor behavior.
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Behavioral cross-sensitization between DOCA-induced sodium appetite and cocaine-induced locomotor behavior.

机译：DOCA诱导的食欲与可卡因诱导的运动行为之间的行为交叉敏化。

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Behavioral sensitization involves increases in the magnitude of a response to a stimulus after repeated exposures to the same response initiator. Administration of psychomotor stimulants and the induction of appetitive motivational states associated with natural reinforcers like sugar and salt are among experimental manipulations producing behavioral sensitization. In rats, repeated administration of the mineralocorticoid agonist deoxycorticosterone acetate (DOCA) initially induces incremental increases in daily hypertonic saline consumption (i.e., sensitization of sodium appetite) in spite of the retention of sodium. The present studies investigated whether sodium appetite sensitization induced by DOCA shares mechanisms similar to those of psychomotor stimulant-induced sensitization, and whether there is evidence for reciprocal cross-sensitization. In Experiments 1 and 3, rats received control or cocaine treatments to induce locomotor sensitization. A week later DOCA (or vehicle) was administered to generate a sodium appetite. Animals pretreated with cocaine showed a greater sodium appetite. In Experiment 2, the order of the putative sensitizing treatments was reversed. Rats first received either a series of DOCA or vehicle treatments either with or without access to saline and were later tested for sensitization of the locomotor response to cocaine. Animals pretreated with DOCA without access to saline showed greater locomotor responses to cocaine than animals receiving vehicle treatments. Together these experiments indicate that treatments generating a sustained salt appetite and producing cocaine-induced psychomotor responses show reciprocal behavioral cross-sensitization. The underlying mechanisms accounting for this relationship may be the fact that psychostimulants and an unresolved craving for sodium can act as potent stressors.
机译：行为敏化涉及重复暴露于相同的反应引发剂后，对刺激的反应幅度增加。心理运动兴奋剂的管理和与天然增强剂（如糖和盐）相关的诱导性动机状态的诱导是产生行为敏化的实验手段。在大鼠中，反复服用盐皮质激素激动剂醋酸脱氧皮质酮（DOCA）最初会引起每日高渗盐水消耗量的增加（即食欲钠的增敏），尽管会保留钠。本研究调查了由DOCA引起的食欲钠致敏是否与精神运动兴奋剂致敏的机制相似，以及是否有相互交叉致敏的证据。在实验1和3中，大鼠接受了对照或可卡因治疗，以引起运动致敏。一周后，给予DOCA（或赋形剂）以产生钠食欲。用可卡因预处理的动物表现出更大的食欲。在实验2中，推定的敏化处理的顺序颠倒了。大鼠首先接受一系列的DOCA或赋形剂治疗，无论是否接触生理盐水，随后都要测试其对可卡因的运动反应的敏感性。经DOCA预处理而无法获得生理盐水的动物比接受载体处理的动物对可卡因的运动反应更大。这些实验一起表明产生持续盐食欲并产生可卡因诱导的精神运动反应的治疗方法表现出相互的交叉敏感性。解释这种关系的潜在机制可能是心理刺激剂和对钠的未解决的渴望可以充当强大的压力源这一事实。

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