• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Double-dissociation of D1 and opioid receptor antagonism effects on the acquisition of sucrose-conditioned flavor preferences in BALB/c and SWR mice
【24h】

Double-dissociation of D1 and opioid receptor antagonism effects on the acquisition of sucrose-conditioned flavor preferences in BALB/c and SWR mice

机译：D1和阿片样物质受体拮抗作用的双重解离对获得蔗糖条件的BALB / c和SWR小鼠的风味偏好的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sugar appetite is influenced by unlearned attractions to sweet taste and learned responses to sugars' taste and post-ingestive actions. In rats, sugar-conditioned flavor preferences (CFP) are attenuated by dopamine D1 (SCH23390: SCH), but not by opioid (naltrexone: NTX), receptor antagonism. Sucrose-CFP occurs in BALB/c and SWR inbred mice that differ in their suppressive effects of SCH and NTX on sucrose intake. The present study examined whether SCH and NTX altered expression of previously learned sucrose-CFP and acquisition (learning) of sucrose-CFP in these strains. In Experiment 1, food-restricted mice were trained (10 one-bottle sessions) to drink a more-preferred flavored (e.g., cherry) 16% sucrose solution (CS +/Sucrose) on odd-numbered days, and a less-preferred flavored (e.g., grape) 0.05% saccharin solution (CS -/Saccharin) on even-numbered days. Two-bottle tests with the flavors mixed in 0.2% saccharin occurred 30 min following vehicle (Veh), SCH (50-800 nmol/kg) or NTX (1-5 mg/kg) assessing preference expression. CS + preference expression in BALB/c and SWR mice following Veh were significantly reduced by SCH and NTX. In Experiment 2, separate groups of BALB/c and SWR mice received Veh, SCH (50 nmol/kg) or NTX (1 mg/kg) injections 30 min prior to daily one-bottle training sessions with the CS +/Sucrose and CS -/Saccharin solutions assessing preference acquisition. Subsequent two-bottle tests with the CS + vs. CS - solutions were conducted without injections. CS +/Sucrose training intakes were reduced by SCH in both strains and by NTX in BALB/c mice. In the initial two-bottle test, sucrose-CFP acquisition was significantly reduced in BALB NTX (54%), but not in BALB SCH (77%) groups relative to the BALB Veh group (85%). In contrast, sucrose-CFP acquisition was significantly reduced in SWR SCH (61%), but not in SWR NTX (83%) groups relative to the SWR Veh group (86%). DA D1 and opioid receptor signaling modulate acquisition and/or expression of sucrose-CFP in mice with significant strain differences observed.
机译：糖食欲受到未学习的甜味吸引力以及对糖味和减味后行为的习得反应的影响。在大鼠中，多巴胺D1（SCH23390：SCH）减弱了糖条件的风味偏好（CFP），但阿片类药物（纳曲酮：NTX）受体拮抗作用并未减弱。蔗糖-CFP发生在BALB / c和SWR近交小鼠中，它们的SCH和NTX对蔗糖摄入的抑制作用不同。本研究检查了SCH和NTX是否改变了这些菌株中先前学习的蔗糖CFP的表达和蔗糖CFP的获得（学习）。在实验1中，训练了饮食受限的小鼠（10次一瓶），在奇数天喝了更偏爱的风味（例如樱桃）的16％蔗糖溶液（CS + /蔗糖），而喝了偏少的在偶数天加味的（例如葡萄）0.05％糖精溶液（CS-/糖精）。在媒介物（Veh），SCH（50-800 nmol / kg）或NTX（1-5 mg / kg）评估偏好表达后30分钟，进行了将两瓶药与0.2％糖精混合的两瓶测试。 Veh后BALB / c和SWR小鼠的CS +偏好表达被SCH和NTX显着降低。在实验2中，分开的BALB / c和SWR小鼠组在每天一次CS + /蔗糖和CS的单瓶训练之前30分钟接受Veh，SCH（50 nmol / kg）或NTX（1 mg / kg）注射-/糖精溶液评估偏好获取。随后使用CS +与CS-溶液进行两瓶测试，无需进样。两种品系中的SCH降低了CS + /蔗糖的训练摄入量，而BALB / c小鼠中的NTX降低了CS + /蔗糖的训练摄入量。在最初的两瓶试验中，相对于BALB Veh组（85％），BALB NTX（54％）中蔗糖-CFP的获得显着降低，而BALB SCH组（77％）中蔗糖-CFP的获得却没有降低。相比之下，相对于SWR Veh组（86％），SWR SCH（61％）的蔗糖-CFP摄取显着降低，但SWR NTX组（83％）却没有。 DA D1和阿片样物质受体信号转导小鼠中蔗糖-CFP的获取和/或表达，观察到明显的品系差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号