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Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1

机译：姜黄素对Niemann-Pick C1小鼠模型神经变性的功效不足

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摘要

In order to determine the efficacy of curcumin in ameliorating symptoms of neurodegeneration in the mouse model of Niemann-Pick C1, a variety of formulations and dosages of curcumin, one comparable to one previously reported as efficacious, were provided orally to Npc1 -/-mice. Plasma levels of curcumin, survival, tests of motor performance, and memory (in some cases) were performed. We found variable, but mild, increases in survival (1.5% to 18%). The greatest increased survival occurred with the highest dose (which was unformulated) while the control for the lipidated formulation (containing phosphatidylcholine and stearic acid) had an equivalent impact and other formulations, while not significantly increased, are also not statistically different in effect from the highest dose. We conclude that curcumin is not a highly efficacious treatment for neurodegeneration in Npc1 -/- mice. Phosphatidylcholine and stearic acid should be studied further.
机译：为了确定姜黄素在改善Niemann-Pick C1小鼠模型中神经退行性症状中的功效，向Npc1-/-小鼠口服提供了多种姜黄素的制剂和剂量，与以前报道的有效剂量相当。 。进行姜黄素的血浆水平，存活率，运动能力测试和记忆力（在某些情况下）的测试。我们发现生存率有所不同，但有轻微的提高（1.5％至18％）。最大的存活率发生在最高剂量下（未配制），而脂化制剂（含有磷脂酰胆碱和硬脂酸）的对照具有同等影响，而其他制剂虽然没有显着增加，但在统计学上与药物的作用无统计学差异。最高剂量。我们得出结论，姜黄素不是Npc1-/-小鼠神经退行性变的高效疗法。磷脂酰胆碱和硬脂酸应进一步研究。

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