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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neonatal domoic acid treatment produces alterations to prepulse inhibition and latent inhibition in adult rats
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Neonatal domoic acid treatment produces alterations to prepulse inhibition and latent inhibition in adult rats

机译：新生儿海藻酸治疗会改变成年大鼠的搏动抑制和潜伏抑制

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Schizophrenia is a complex and severe mental disorder characterized by positive, negative and cognitive symptoms. Characteristic behavioral alterations reflecting these categories of symptoms have been observed in many animal models of this disorder, and are consistent with those manifested in the clinical population. The purpose of this study was to determine whether early alterations in glutamate signaling would result in alterations to prepulse inhibition (PPI) and latent inhibition (LI); two assessments used for evaluating putative novel animal models with relevance to schizophrenia. In the present experiment, daily subcutaneous (s.c.) injections of 20 μg/kg of domoic acid (DOM) were administered to rat pups from postnatal days (PND) 8-14. When tested as adults, DOM treated rats displayed deficits in PPI that were dependant on both sex and time of day. No differences in startle amplitude, habituation, or movement were found during any test, indicating that the PPI deficits seen could not be attributed to baseline startle differences. Deficits in LI were also apparent when adult rats were tested using a conditioned taste aversion task, with DOM-treated animals displaying a significantly suppressed LI. These results suggest that early treatment with DOM may serve as a useful tool to model schizophrenia which in turn may lead to a better understanding of the contribution of glutamate, and in particular, kainate receptors, to the development and/or manifestation of schizophrenia or schizophrenia-like symptoms in the clinical population.
机译：精神分裂症是一种复杂且严重的精神障碍，其特征是阳性，阴性和认知症状。在这种疾病的许多动物模型中都观察到了反映这些症状类别的特征性行为改变，并且与临床人群中表现出的行为改变一致。这项研究的目的是确定谷氨酸信号的早期改变是否会导致前脉冲抑制（PPI）和潜伏抑制（LI）的改变。用于评估与精神分裂症有关的新型动物模型的两项评估。在本实验中，每天从皮下（s.c.）皮下注射20μg/ kg的多摩酸（DOM），用于从出生后（PND）8-14天开始的幼崽。当以成年测试时，DOM处理的大鼠表现出PPI缺陷，这取决于性别和一天中的时间。在任何测试中均未发现惊吓幅度，习惯或运动方面的差异，这表明所观察到的PPI缺陷不能归因于基线惊吓差异。当使用条件性味觉厌恶任务测试成年大鼠时，LI的缺陷也很明显，DOM处理的动物表现出明显的LI抑制。这些结果表明，用DOM进行早期治疗可能是对精神分裂症进行建模的有用工具，进而可以更好地了解谷氨酸，尤其是海藻酸盐受体对精神分裂症或精神分裂症的发展和/或表现的贡献。临床人群中的类似症状。

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