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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Oleamide restores sleep in adult rats that were subjected to maternal separation
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Oleamide restores sleep in adult rats that were subjected to maternal separation

机译：油酰胺可恢复成年母鼠的睡眠

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摘要

Maternal separation (MS) induces a series of changes in rats' behavior; among them a reduction in spontaneous sleep. One potentially impaired system is the endocannabinoid system (eCBs), since it contributes to generate sleep. To investigate if there are situations early in life that affect the eCBs, which would contribute to make rats vulnerable to suffering insomnia, we studied the rodent model of MS. Rats were separated from their mothers for 3 h-periods daily, from postnatal day (PND) 2 to PND 16. Once they gained 250 g of body weight (adult rats), they were implanted with electrodes to record the sleep-waking cycle (SWC). MS rats and non-MS (NMS) siblings were assigned to one of the following groups: vehicle, oleamide (OLE, an agonist of the cannabinoid receptor 1, CB1R), OLE + AM251 (an antagonist of the CB1R) and AM251 alone. Expression of the CBR1 receptor was also analyzed in the frontal cortex (FCx) and in the hippocampus (HIP) of both NMS and MS rats. Results indicated that MS induced a reduction in both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep with the consequent increase in waking (W) as compared to NMS siblings. OLE normalized the SWC, and AM251 blocked such an effect. CB1R expression was reduced in the FCx and in the HIP of MS rats. Our results indicate that MS reduces sleep and CB1R expression and OLE improves sleep in adult rats.
机译：母体分离（MS）引起大鼠行为的一系列变化。其中减少了自发睡眠。一种可能受损的系统是内源性大麻素系统（eCBs），因为它有助于产生睡眠。为了研究生命早期是否存在影响eCB的情况，这会导致大鼠容易遭受失眠，我们研究了MS的啮齿动物模型。从产后一天（PND）2到PND 16，每天将大鼠与它们的母亲分开3小时。一旦它们增加了250 g的体重（成年大鼠），就将它们植入电极以记录睡眠-觉醒周期（ SWC）。将MS大鼠和非MS（NMS）兄弟姐妹分为以下一组：媒介物，油酰胺（OLE，大麻素受体1 CB1R的激动剂），OLE + AM251（CB1R的拮抗剂）和仅AM251。还分析了NMS和MS大鼠的额叶皮层（FCx）和海马（HIP）中CBR1受体的表达。结果表明，与NMS兄弟姐妹相比，MS引起了非快速眼动（NREM）和快速眼动（REM）睡眠的减少，因此醒来（W）的增加。 OLE标准化了SWC，AM251阻止了这种影响。 MS大鼠的FCx和HIP中的CB1R表达降低。我们的结果表明，MS可以降低成年大鼠的睡眠和CB1R表达，而OLE可以改善睡眠。

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