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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Strain differences in delay discounting between Lewis and Fischer 344 rats at baseline and following acute and chronic administration of d-amphetamine
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Strain differences in delay discounting between Lewis and Fischer 344 rats at baseline and following acute and chronic administration of d-amphetamine

机译：Lewis和Fischer 344大鼠在基线以及急性和慢性给予d-苯异丙胺后延迟贴现中的应变差异

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摘要

Stimulant drugs have been shown either to increase or decrease rates of delay discounting (impulsive choice). These mixed findings may result from genetic, neurochemical, or environmental factors. Lewis (LEW) and Fischer 344 (F344) rats have neurochemical and behavioral differences that may be relevant to delay discounting and were used to examine effects of acute and chronic administration of d-amphetamine (d-AMP) on impulsive choice using a within-session delay-discounting procedure. Male LEW (n = 8) and F344 (n = 8) rats chose between one food pellet delivered immediately and three food pellets delivered after an increasing delay. Saline and d-AMP (0.1, 0.3, 1.0, and 1.7 mg/kg) were tested acutely and during chronic d-AMP exposure. Choice for the larger reinforcer decreased as the delay to its presentation increased for both strains at baseline. LEW rats made more impulsive choices than F344 rats as indicated by shorter indifference points, and this is consistent with previous research. Acute administration of d-AMP dose dependently increased larger-reinforcer choice and area under the curve (AUC) for LEW, but not F344 rats. During chronic exposure to d-AMP, larger-reinforcer choice and AUC increased relative to acute administration for F344 rats responding in shorter delay series, but not for F344 rats responding in longer delay series or for LEW rats. Differential effects of acute and chronic administration of d-AMP on impulsive choice in LEW and F344 rats may be a result of various factors, including genetic, neurochemical, and environmental variables. Future research should attempt to tease apart the relative contribution of each of these factors on impulsive choice.
机译：刺激性药物已显示出增加或减少延迟贴现率（冲动选择）。这些混杂的发现可能是由于遗传，神经化学或环境因素造成的。 Lewis（LEW）和Fischer 344（F344）大鼠具有神经化学和行为差异，这些差异可能与延迟贴现有关，并被用于通过以下方法检查急性和慢性给予d-苯丙胺（d-AMP）对冲动选择的影响：会话延迟折扣过程。雄性LEW（n = 8）和F344（n = 8）大鼠在立即递送的一种食物颗粒和增加的延迟后交付的三种食物颗粒之间进行选择。急性和长期d-AMP暴露期间测试了盐水和d-AMP（0.1、0.3、1.0和1.7 mg / kg）。随着基线时两种菌株的出现延迟增加，对较大增强剂的选择减少。较短的冷漠点表明，LEW大鼠比F344大鼠有更多的冲动选择，这与以前的研究一致。 d-AMP剂量的急性给药依旧增加了LEW的大补强剂选择和曲线下面积（AUC），但F344大鼠没有。在长期暴露于d-AMP的过程中，相对于急性给药，对于延迟时间较短的F344大鼠，较大的增强剂选择和AUC相对增加，但对于延迟时间较长的F344大鼠或LEW大鼠则没有。急性和慢性给予d-AMP对LEW和F344大鼠冲动选择的不同作用可能是多种因素导致的，包括遗传，神经化学和环境变量。未来的研究应该尝试找出这些因素对冲动选择的相对贡献。

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