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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice
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In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice

机译：α-（苯基硒基）苯乙酮对小鼠的体外抗氧化活性和体内抗抑郁样作用

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In this study, the antioxidant and antidepressant-like effects of α-(phenylselanyl) acetophenone (PSAP), an organoselenium compound, were investigated. To assess the in vitro antioxidant properties, PSAP was evaluated in four test systems (DPPH, ABTS, FRAP and inhibition of lipid peroxidation). PSAP (100-500 μM) showed potent antioxidant activity and protected against lipid peroxidation. Additionally, we investigated whether PSAP, when administered in mice (100, 200 and 400 mg/kg, per oral, p.o.), could cause acute toxicity. Our results demonstrated that PSAP did not cause the death of any animal, significantly reduce body weight or cause any oxidative tissue stress following treatment. This study also evaluated the effect of PSAP (0.1-10 mg/kg, p.o) on mice in a forced swim test (FST) and tail suspension test (TST), assays that are predictive of depressant activity and motor activity in the open-field. PSAP (5-10 mg/kg) significantly reduced immobility time in the FST and TST without affecting motor activity. In addition, the antidepressant-like effect caused by PSAP (5 m/kg, p.o) in mice during the TST was dependent on an interaction with the serotonergic system (5-HT 1A receptors), but not with the noradrenergic, dopaminergic or adenosinergic system. Together, these results suggest that PSAP possesses antioxidant and antidepressant-like properties and may be of interest as a therapeutic agent for the treatment of depressive disorders.
机译：在这项研究中，研究了有机硒化合物α-（苯基硒基）苯乙酮（PSAP）的抗氧化和抗抑郁样作用。为了评估体外抗氧化性能，在四个测试系统（DPPH，ABTS，FRAP和脂质过氧化抑制）中评估了PSAP。 PSAP（100-500μM）显示出有效的抗氧化活性，并保护其免受脂质过氧化作用。此外，我们调查了PSAP在小鼠体内（口服，口服）分别为100、200和400 mg / kg时是否会引起急性毒性。我们的结果表明，PSAP在治疗后不会导致任何动物死亡，显着减轻体重或引起任何氧化性组织应激。这项研究还评估了PSAP（0.1-10 mg / kg，口服）在强迫游泳试验（FST）和尾部悬吊试验（TST）中对小鼠的影响，这些试验可预测开放性抑郁症活动和运动活动领域。 PSAP（5-10 mg / kg）显着减少了FST和TST中的固定时间，而不会影响运动活动。此外，TST在小鼠中由PSAP（5 m / kg，po）引起的抗抑郁样作用取决于与血清素能系统（5-HT 1A受体）的相互作用，而不与去甲肾上腺素能，多巴胺能或腺苷能相互作用系统。总之，这些结果表明，PSAP具有抗氧化剂和抗抑郁剂样的性质，并且作为治疗抑郁症的治疗剂可能是令人感兴趣的。

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