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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine.
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The mu/kappa agonist nalbuphine attenuates sensitization to the behavioral effects of cocaine.

机译：mu / kappa激动剂纳布啡可减弱对可卡因行为影响的敏感性。

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摘要

Sensitization refers to an increase in sensitivity to a drug and is believed to play a role in the etiology of substance use disorders. The purpose of the present study was to evaluate the ability of the mixed mu/kappa agonist nalbuphine to modulate sensitization to the locomotor and positive reinforcing effects of cocaine. Rats were habituated to a locomotor activity chamber and treated with saline (1.0 ml/kg, ip), cocaine (10 mg/kg, ip), or cocaine+nalbuphine (10 mg/kg, ip) every day for 10 days. Following locomotor activity testing, rats were implanted with intravenous catheters and cocaine self-administration was examined on fixed ratio (FR) and progressive ratio (PR) schedules of reinforcement. Rats treated with cocaine exhibited a progressive increase in locomotor activity over the 10-day treatment period, and this effect was significantly reduced in rats treated with cocaine+nalbuphine. In self-administration tests, rats treated with cocaine exhibited significantly higher levels of responding at a threshold dose of cocaine (0.03 mg/kg/infusion) on both FR and PR schedules than rats treated with saline. This increase in responding at a threshold dose of cocaine was blocked completely in rats treated with cocaine+nalbuphine. These data suggest that nalbuphine attenuates the development of sensitization to the behavioral effects of cocaine.
机译：致敏是指对药物的敏感性增加，并且被认为在物质使用障碍的病因中起作用。本研究的目的是评估混合的mu /κ激动剂纳布啡调节可卡因对运动的敏感性和正增强作用的能力。将大鼠习惯于运动活动室并每天用盐水（1.0 ml / kg，ip），可卡因（10 mg / kg，ip）或可卡因+纳布啡（10 mg / kg，ip）处理10天。运动功能测试后，将大鼠植入静脉内导管，并按照固定比例（FR）和渐进比例（PR）加强计划检查可卡因的自我给药。用可卡因治疗的大鼠在10天的治疗期内表现出自发活动的进行性增加，而用可卡因+纳布啡治疗的大鼠的这种作用明显降低。在自我给药测试中，在可卡因阈值剂量（0.03 mg / kg /滴注）下，用可卡因治疗的大鼠在FR和PR方案中的反应水平均显着高于用盐水治疗的大鼠。在可卡因+纳布啡治疗的大鼠中，可卡因阈值剂量反应的这种增加被完全阻止。这些数据表明，纳布啡减弱了对可卡因行为影响的敏化作用。

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