• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cue-induced conditioned activity does not incubate but is mediated by the basolateral amygdala.
【24h】

Cue-induced conditioned activity does not incubate but is mediated by the basolateral amygdala.

机译：提示诱导的条件活性没有被孵化，而是由基底外侧杏仁核介导的。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Re-exposure to drug-associated cues causes significant drug craving in recovering addicts, which may precipitate relapse. In animal models of craving, drug-seeking responses for contingent delivery of drug-associated cues sensitizes or "incubates" across drug withdrawal. To date there is limited evidence supporting an incubation effect for behaviors mediated by non-contingent presentation of drug-associated cues. Here we used a model of cue-induced conditioned activity to determine if the conditioned locomotor response to a non-contingent presentation of a drug-associated cue sensitizes across drug withdrawal. In addition, because cue-induced drug-seeking responses are mediated by the rostral basolateral amygdala (BLA), we investigated whether this structure is critical for the expression of cue-induced conditioned activity. A conditioned association between cocaine (15mg/kg) and a compound discrete cue (flashing bicycle light+a metronome) was established over 12 conditioning sessions in male Sprague-Dawley rats. In experiment 1, cue-induced conditioned activity was assessed on 3 occasions: 3, 14 and 28days following the final drug-cue conditioning session. Cocaine-conditioned rats demonstrated reliable cue-induced conditioned activity across all 3 test sessions, however there was no evidence of an incubation effect. To determine whether repeated testing prevented the observation of an incubation effect, rats in experiment 2 were tested either 3days or 28days following conditioning; again no incubation effect was observed. In experiment 3, either saline or the GABAA receptor agonist muscimol was infused prior to testing. Intra-BLA infusions of muscimol prevented the expression of cue-induced conditioned activity. These data support the role of the rBLA in mediating conditioned responses to drug-associated cues. The failure to observe an incubation effect for cue-induced conditioned activity may point to a fundamental difference in the manner by which contingent and non-contingent presentations of drug-associated cues influence behavior.
机译：再次暴露于与毒品有关的线索会导致正在戒毒的成瘾者对毒品的渴望很大，这可能会促使复发。在渴望的动物模型中，针对与药物相关的线索的偶然性传递的寻求药物反应会在整个戒断过程中使药物敏感或“温育”。迄今为止，仅有有限的证据支持对药物相关线索的非或然呈现所介导的行为具有孵化作用。在这里，我们使用提示诱导条件性活动的模型来确定是否对药物相关提示的非偶然性表达的条件性运动反应在停药期间敏感。另外，由于提示诱导的药物寻求反应是由延髓基底外侧杏仁核（BLA）介导的，所以我们研究了这种结构对于提示诱导的条件活性的表达是否至关重要。在雄性Sprague-Dawley大鼠中，在12个适应期中建立了可卡因（15mg / kg）与复合离散提示（闪烁的自行车灯光+节拍器）之间的条件关联。在实验1中，在最终的药物提示调理阶段后的3、14和28天，对3种情况进行了提示诱导的条件调节活动的评估。可卡因调理的大鼠在所有3个测试阶段均表现出可靠的提示诱导的调理活性，但是没有证据表明有孵化作用。为了确定重复测试是否阻止了对孵化效果的观察，对实验2中的大鼠在条件调节后3天或28天进行了测试;再次没有观察到孵化效果。在实验3中，在测试前先注入生理盐水或GABAA受体激动剂麝香酚。 BLA内注射麝香酚阻止了提示诱导的条件活性的表达。这些数据支持rBLA在介导对药物相关线索的条件反应中的作用。未能观察到提示诱导的条件活性的孵化效果，可能表明药物相关线索的或有和非有条件呈现方式影响行为的方式存在根本差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号