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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators.
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The analgesic effect of crotoxin on neuropathic pain is mediated by central muscarinic receptors and 5-lipoxygenase-derived mediators.

机译：crotoxin对神经性疼痛的镇痛作用由中毒蕈碱受体和5-脂氧合酶衍生的介体介导。

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摘要

Crotoxin (CTX), a neurotoxin isolated from the venom of the South American rattlesnake Crotalus durissus terrificus, induces analgesia. In this study, we evaluated the antinociceptive effect of CTX in a model of neuropathic pain induced by rat sciatic nerve transection. Hyperalgesia was detected 2 h after nerve transection and persisted for 64 days. Immersion of proximal and distal nerve stumps in CTX solution (0.01 mM for 10 s), immediately after nerve transection, blocked hyperalgesia. The antinociceptive effect of CTX was long-lasting, since it was detected 2 h after treatment and persisted for 64 days. CTX also delayed, but did not block, neurectomy-induced neuroma formation. The effect of CTX was blocked by zileuton (100 mg/kg, p.o.) and atropine (10 mg/kg, i.p.), and reduced by yohimbine (2 mg/kg, i.p.) and methysergide (5 mg/kg, i.p.). On the other hand, indomethacin (4 mg/kg, i.v.), naloxone (1 mg/kg, i.p.), and N-methyl atropine (30 mg/kg, i.p.) did not interfere with the effect of CTX. These results indicate that CTX induces a long-lasting antinociceptive effect in neuropathic pain, which is mediated by activation of central muscarinic receptors and partially, by activation of alpha-adrenoceptors and 5-HT receptors. Eicosanoids derived from the lipoxygenase pathway modulate the action of crotoxin.
机译：Crotoxin（CTX）是一种从南美响尾蛇Crotalus durissus terrificus的毒液中分离出来的神经毒素，可引起镇痛作用。在这项研究中，我们评估了CTX在大鼠坐骨神经横断所致神经性疼痛模型中的抗伤害作用。神经横切后2小时检测到痛觉过敏，并持续了64天。神经横断后立即将近端和远端神经残端浸入CTX溶液（0.01 mM，持续10 s），阻止痛觉过敏。 CTX的抗伤害感受作用持久，因为在治疗后2小时即可检测到并持续64天。 CTX还可以延迟但不阻止神经切除术诱导的神经瘤形成。齐留通（100 mg / kg，p.o.）和阿托品（10 mg / kg，i.p.）阻断了CTX的作用，育亨宾（2 mg / kg，i.p.）和美塞麦肽（5 mg / kg，i.p.）减弱了CTX的作用。另一方面，消炎痛（4mg / kg，腹腔注射），纳洛酮（1mg / kg，腹腔注射）和N-甲基阿托品（30mg / kg，腹腔注射）不干扰CTX的作用。这些结果表明，CTX在神经性疼痛中诱导持久的抗伤害感受作用，其作用是由中央毒蕈碱受体的活化介导的，部分是由α-肾上腺素能受体和5-HT受体的活化介导的。从脂氧合酶途径衍生的类花生酸调节crotoxin的作用。

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