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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Biphasic emetic response of cyclophosphamide in the ferret.
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Biphasic emetic response of cyclophosphamide in the ferret.

机译：雪貂中环磷酰胺的双相催吐反应。

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摘要

Cyclophosphamide (177 mg/kg, IV: n = 8) produced a biphasic emetic response in the ferret with a mean +/- SE of 23.3 +/- 4.0 emetic episodes during a 4-h observation period. The emetic profile of cyclophosphamide showed a first phase with 18.6 +/- 3.9 episodes and a second phase with 4.7 +/- 1.2 episodes. Ondansetron (0.07 and 0.13 mg/kg, IV) and droperidol (0.25 and 0.79 mg/kg, IV) significantly reduced the number of emetic episodes in the first phase. Metoclopramide (2.24, 4.08, and 7.07 mg/kg, IV) also significantly reduced the number of emetic episodes in the first phase, and the dose of 7.07 mg/kg completely prevented emetic episodes in the second phase. In addition, ondansetron-treated ferrets (0.04, 0.07, and 0.13 mg/kg, IV) had a significant increase in the number of emetic episodes in the second phase.
机译：在4小时的观察期内，环磷酰胺（177 mg / kg，IV：n = 8）在雪貂中产生了双相催吐反应，平均+/- SE为23.3 +/- 4.0催吐。环磷酰胺的催吐曲线显示第一阶段为18.6 +/- 3.9次发作，第二阶段为4.7 +/- 1.2发作。恩丹西酮（0.07和0.13 mg / kg，静脉注射）和氟哌啶（0.25和0.79 mg / kg，静脉注射）显着减少了第一阶段的催吐次数。甲氧氯普胺（2.24、4.08和7.07 mg / kg，静脉注射）也显着减少了第一阶段的呕吐发作次数，而7.07 mg / kg的剂量则完全阻止了第二阶段的呕吐发作。此外，用恩丹西酮处理的雪貂（0.04、0.07和0.13 mg / kg，IV）在第二阶段的催吐次数显着增加。

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